Research and KE

Knowledge Exchange and Impact

Patents Filed

2019

Silver-/gold-compounds and methods thereof

Area: Healthcare

Inventor: Sun Hongzhe; Ho Pak Leung; Wang Runming; Li Hongyan; Zhang Qi

US provisional patent on silver and gold compounds as a mobile colistin resistant proteins (MCRs) inhibitor to overcome infections by superbugs.

 

Cyclic peptides and bicyclic peptides and methods thereof

Area: Healthcare

Inventor: Li Xuechen; Zhang Yue 

A new method for producing cyclic peptides fordrug discovery applications.

 

Luminescent cyclometalated tridentate ligand-containing gold(III) compounds with aryl auxiliary ligand for organic light-emitting devices and their preparation thereof

Area: Organic light-emitting devices

Inventor: Yam, V.W.W.; Tang, M.C.; Chan, M.Y.; Lee, C.H.; Li, Lok Kwan

US Non-Provisional Patent related to the development of gold(III) compounds with aryl auxilliary ligand and their applications for OLEDs.

 

Luminescent cyclometalated tridentate ligand-containing gold(III) compounds with aryl auxiliary ligand for organic light-emitting devices and their preparation thereof

Area: Organic light-emitting devices

Inventor: Yam, V.W.W.; Tang, M.C.; Chan, M.Y.; Lee, C.H.; Li, Lok Kwan

PCT Patent related to the development of gold(III) compounds with aryl auxilliary ligand and their applications for OLEDs.

 

Luminescent tetradentate ligand-containing gold(III) compounds for organic light-emitting devices and their preparation

Area: Organic light-emitting devices

Inventor: Yam, V.W.W.; Tang, M.C.; Li, L.K.; Chan, M.Y.

US Non-Provisional Patent related to the development of gold(III) compounds with tetradentate ligand and their applications for OLEDs.

 

Luminescent tetradentate ligand-containing gold(III) compounds for organic light-emitting devices and their preparation

Area: Organic light-emitting devices

Inventor: Yam, V.W.W.; Tang, M.C.; Li, L.K.; Chan, M.Y.

Chinese Patent related to the development of gold(III) compounds with tetradentate ligand and their applications for OLEDs.

 

Luminescent gold(III) compound, method for preparing the same, and organic light-emitting device using the same

Area: Organic light-emitting devices

Inventor: Yam, V.W.W.; Lee, C.H.; Tang, M.C.; Chan, M.Y.

PCT Patent related to the development of gold(III) compounds with Group 14 element-containing ligand and their applications for OLEDs.

 

Yeats inhibitors and methods od use thereof

Area: Healthcare

Inventor: Li, Xiang David; Li, Xin

Functionalized peptides as YEATS domain inhibitors with potential anti-leukemia activity.

 

2015

Photovoltaic conversion element and photovoltaic cell

Area: Energy

Inventor: Che Chi Ming

Described herein are organic photovoltaic (OPV) cells using gold complex(es) with as chemical structure of Structure I as active material: wherein, wherein R1-R15 are independently hydrogen, halogen, hydroxyl, an unsubstituted alkyl, a substituted alkyl, cycloalkyl, an unsubstituted aryl, a substituted aryl, acyl, alkoxy, acyloxy, amino, alkylamino, nitro, acylamino, aralkyl, cyano, carboxyl, thio, styryl, aminocarbonyl, carbamoyl, aryloxycarbonyl, phenoxycarbonyl, hydroxyalkyl, or an alkoxycarbonyl group. The OPV cell can be fabricated by thermal deposition or solution process such as spin coat and printing.

 

Method and system of atmospheric pressure megavolt electrostatic field ionization desorption (APME-FID)

Area: Analytical system and method

Inventor: Ng Kwan Ming

Atmvospheric pressure megavolt electrostatic field ionization desorption (APME-FID) method generates ions directly from the surface of sample (2) connected to a high electrical voltage generator (1) at megavolt conditions. Megavolt electrostatic potential is generated and gradually accumulated directly on the sample (2) surface by a Van de Graaff generator without causing damage to the sample (2). Therefore, when coupled with mass spectrometric system, the APME-FID-MS method enables direct detection of analytes on the surface of samples in different sizes and diverse types.

 

Solid supported gold nanoparticles, methods of use thereof, and methods for making same

Year: 2015 / 2013

Area: Healthcare

Inventor: Che Chi Ming

Solid-supported gold nanoparticles for use as a catalyst for the synthesis of quinolines from anilines and aldehydes using oxygen as an oxidant are provided. Also provided are a method for the preparation of SiO2-supported gold nanoparticles by in situ deposition of gold nanoparticles to silica gel and a method for synthesizing quinolines from anilines and aldehydes using oxygen as an oxidant.

 

Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue

Area: Healthcare

Inventor: Li Xuechen and others

A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogues can include a different fatty acid in the side arm of the daptomycin analogue.

 

Dendrimers containing luminescent gold (III) compounds for organic light-emitting devices and their preparation

Area: Organic light-emitting devices

Inventor: Yam Wing Wah Vivian and others

A novel class of saturated or conjugated dendrimers containing at least one strong sigma-donating group coordinated to cyclometalated tridentate gold(III) compounds having the chemical structure depicted by generic formula: wherein: (a) [Au] is a cyclometalated tridentate gold(III) group; (b) Unit A is a sigma-donating chemical group; (c) Unit B is a central part of the dendrons comprising a branch point of component dendrimers; (d) Unit C is optional surface groups or dendrons of the dendrimers; (e) n=0 or 1.

 

2014

Antifungal compound and uses thereof

Area: Healthcare

Inventor: Yang Dan and and others

Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.

 

Method of using binuclear gold (i) compounds for cancer treatment

Area: Healthcare

Inventor: Che Chi Ming

Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.

 

Novel gold (III) complexes containing n-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection

Area: Healthcare

Inventor: Che Chi Ming and others

Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growthin vivo.

 

Functionalized triplet emitters for electro-luminescent devices

Area: Organic light-emitting devices

Inventor: Chan Wai Kin and and others

This invention pertains to organo-metallic complexes for opto-electronic and sensory devices and their use in such opto-electronic and sensory devices. The organo-metallic complex (triplet emitter) of the invention consists of a metal center and chelate ligands. At least one of these chelate ligands comprises an aromatic or fused aromatic ring(s). Each of these ligands is covalently substituted with at least one, preferably two charge transport groups (ctg). The metal center can additionally be coordinated by a spectator ligand. The presence of two ctgs at each ligand results in distinct advantages - in particular for applications in organic light emitting diodes (OLEDs) - compared to complexes known in the state of the art: - The charge transport units facilitate hole and/or electron transport to the molecular center and allow for efficient exciton formation directly on the emitter complex. - The presence of the ctgs on each ligand provides a good shielding with respect to interactions to the environment. Thus, emission quenching is strongly reduced and materials with high emission quantum yields are obtained. - The presence of the ctgs on each ligand increases the separations between the emitting cores of different molecules and thus reduces undesired quenching by triplet-triplet annihilation or self-quenching effects. - The complexes of the invention are highly soluble in many organic solvents and thus are well suited for wet-chemical processing.

 

Luminescent gold (III) compounds containing bidentate ligand for organic light-emitting devices and their preparation

Year: 2014 / 2013

Area: Organic light-emitting devices

Inventor: Yam Wing Wah Vivian and others

Embodiments of the invention are directed to luminescent gold(III) compounds contains a bidentate ligand with at least one strong s-donating group, a method of preparation of these compounds and the use of these compounds in organic light emitting devices.. The gold (III) compounds have the chemical structure: Formular (I) wherein: X Is a nitrogen atom; Y is selected from a carbon or a nitrogen atom; A-B is a substituted or unsubstituted cyclometalating ligand (for Y=C) or diimine ligand (for Y=N); where A and B are cyclic structure derivatives; R 1and R2 are optionally substituted carbon donor ligands attached to the gold atom, with the proviso that R1 and R2 are not -CH3, -CH2SiMe3, mesityl, pentaflurophenyl, -CH2C(O)R', -CH(R)SO2CH(R)-, -C6H4N=NC6H5, and wherein R1 and R2 can optionally be combined into a bidentate ligand; and n is greater or equal to zero.

 

Phosphorescent material, their preparations and applications

Year: 2014 / 2012

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

The subject invention is directed to tetradentate bis-(NHC carbenes) alkylene ligand Pt(II) complexes, tetradentate bis-(NHC carbenes) alkylene ligands, and its ligand precursors, for preparation of the Pt(II) complexes. The Pt(II) complexes show a deep blue emission with an improved quantum efficiency and can be used for fabrication of OLEDs with an electroluminescence layer that comprise the bis-(NHC carbenes) alkylene ligand Pt(II) complexes.

 

2013

Diarylamine-based fluorogenic probes for detection of peroxynitrite

Area: Fluorescent probes

Inventor: Yang Dan and others

Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

 

Luminescent gold (III) compounds for organic light-emitting devices and their preparation

Area: Organic light-emitting devices

Inventor: Yam Wing Wah Vivian and others

A novel class of saturated or conjugated dendrimers containing at least one strong sigma-donating group coordinated to cyclometalated tridentate gold(III) compounds having the chemical structure depicted by generic formula: wherein: (a) [Au] is a cyclometalated tridentate gold(III) group; (b) Unit A is a sigma-donating chemical group; (c) Unit B is a central part of the dendrons comprising a branch point of component dendrimers; (d) Unit C is optional surface groups or dendrons of the dendrimers; (e) n=0 or 1.

 

Palladium complexes for organic light-emitting diodes

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Subject matter disclosed herein relates to a series of palladium based materials, their preparation method and their applications in an organic light-emitting diode (OLED).

 

Platinum (II) complexes for OLED applications

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

The current invention relates to novel platinum(II) based organometallic materials. These materials show high emission quantum efficiencies and low self-quenching constant. Also provided are high efficiency, green to orange emitting organic light-emitting diode (OLED) that are fabricated using platinum(II) based organometallic materials as the light-emitting material. The organometallic materials of the invention are soluble in common solvents; therefore, solution process methods such as spin coating and printing can be used for device fabrication. The devices fabricated from these materials show low efficiency roll-off.

 

Light-emitting organic metal material

Area: Organic light-emitting devices

Inventor: Yam Wing Wah Vivian and others

A luminous organic metal material is synthesized, and has stability enough for sublimation and vacuum deposition is electrically phosphorescent, and can be used for organic LEDs (OLEDs) because of its colour from organe to red, high efficiency and high brightness. This new-light emitting material of formulas I and II is disclosed.

 

2012

Method for convertion of terminal alkenes to aldehydes using ruthenium (IV) porphrin catalysts

Year: 2012 / 2009 / 2006

Area: Catalysis

Inventor: Che Chi Ming and others

Aldehydes were obtained in excellent yields from ruthenium-porphyrin-catalyzed oxidation of various terminal alkenes with 2,6-dichloropyridine N-oxide under mild conditions. The aldehydes generated from these ruthenium-catalyzed alkene oxidation reactions can be used in-situ for olefination reactions with ethyl diazoacetate in the presence of PPh3, leading to one-pot diazoacetate olefination starting from alkenes.

 

Antiviral compounds and methods of making and using thereof

Year: 2012 / 2011

Area: Healthcare

Inventor: Yang Dan and others

Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

 

Hydroxy-substituted cold(III) porphyrin complexes as histone deacetylase inhibitors

Year: 2012 / 2011

Area: Healthcare

Inventor: Che Chi Ming and others

A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of or a pharmaceutically acceptable salt thereof, wherein: -R is selected from the group consisting of -OH, -CH2OH, C2H4OH, -C3H6OH or -C4H8OH; and X is independently a pharmaceutically acceptable counter-ion.

 

Pharmaceutical composition containing cyclometalated n-heterocyclic carbene complexes for cancer treatment

Year: 2012 / 2011

Area: Healthcare

Inventor: Che Chi Ming and others

A pharmaceutical composition comprising one or more of the following ruthenium oxalate compounds Formulae (I , II , III , and IV) as an active ingredient . The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection.

 

Pharmaceutical composition having a ruthenium oxalato compound and method of using the same

Year: 2012 / 2011 / 2010 / 2009 / 2007

Area: Healthcare

Inventor: Che Chi Ming and others

A pharmaceutical composition comprising one or more of the following ruthenium oxalate compounds Formulae (I , II , III , and IV) as an active ingredient . The pharmaceutical composition can be used for the treatment of viral-infected patients or prophylactic treatment of patients at risk from viral infection .

 

Label-Free Optical Sensing and Characterization of Biomolecules by d8 or d10 Metal Complexes

Year: 2012 / 2011

Area: Optical sensors

Inventor: Yam Wing Wah Vivian and others

The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal . . . Metal interactions, [pi] . . . [pi] interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, polyaspartate, polyglutamate, using a composition comprising a charged d8 or d10 metal complex.

 

Luminescent gold (III) compounds, their preparation, and light-emitting devices containing same

Year: 2012 / 2009

Area: Organic light-emitting devices

Inventor: Yam Wing Wah Vivian and others

A class of luminescent gold(iii) compounds with a tridentate ligand and at least one strong sigma-donating group having the chemical structure represented by the general formula (i): wherein r1-r4 each independently represent the group containing hydrogen, halogen, alkynyl, substituted alkynyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxyl, substituted alkoxyl, amino, substituted amino, cyano, nitro, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, aryloxycarbonyl, mono- or dialkylaminocarbonyl, alkylcarbonyloxy, arylcarbonyloxy, aryloxy, alkoxycarbonyl, aryloxycarbonyloxy group, and the like; x, y and z each independently represent a heteroatom or a carbon; represents an aromatic or heterocyclic 5- or 6-membered ring; alpha and beta each independently represent a bridge for an aromatic or heterocyclic 5- or 6-membered ring or represent a break for non-cyclic moiety; c-x, c-y and c-z each independently represent a single bond or double bond; n represents a zero or an integer; p, q and r represent positive integers.

 

Platinum (II) tetradentate o-n-c-n complexes for organic light-emitting diode applications

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Described are novel platinum (II) containing organometallic materials. These materials show green to orange emissions with high emission quantum efficiencies. Using the materials as emitting materials; pure green emitting organic light-emitting diodes can be fabricated. Since the novel platinum (II) containing organometallic materials are soluble in common solvents, solution process methods such as spin coating and printing can be used for device fabrication.

 

Platinum (II) isoquinoline-pyridine-benzene based complexes, preparing method thereof, and organic light-emitting diodes made therefrom

Area: Organic light-emitting devices

Year: 2012 / 2010

Inventor: Che Chi Ming and others

The invention provides a class of organometallic complexes comprising a tridentate isoquinoline-pyridine-benzene based ligand, a mono-dentate ligand and a platinum (II) center which show high emission quantum efficiency and good thermal stability. This invention also discloses organometallic complexes in organic light-emitting diode (OLED) including them.

 

Photochromic diarylethene containing coordination compounds and the production thereof

Area: Organic light-emitting devices

Year: 2012 / 2011 / 2010 / 2008

Inventor: Yam Wing Wah Vivian and others

Diarylethene-containing ligands and their coordination compounds are described. The ligands display photochromism with UV excitation, while the coordination compounds display photochromism with both excitation in the UV region and excitation into lower energy absorption bands characteristic of the coordination compounds, through which the excitation wavelengths for the photocyclization can be extended from [lambda]!<=340 nm to wavelengths beyond 470 nm. Switching of the luminescence properties of the compounds has also been achieved through photochromic reactions.

 

2011

Bis-(8-quinolinolato-N,O) platinum(Ii) based organic photovoltaic cell

Area: Energy

Inventor: Che Chi Ming and others

Organic photovoltaic (OPV) cells and methods of forming the same are provided. An OPV cell can include an organic photoactive layer comprising bis-(8-quinolinolato-N,O) platinum (II) (PtQ2) having a general structure disclosed herein as Structure I. A method of forming an OPV cell can include forming an organic photoactive layer on a substrate, which can include a transparent electrode. The organic photoactive layer can comprises PtQ2 having the general structure of Structure I.

 

Catalyst for hydrogen generation from small organic molecules

Area: Energy

Inventor: Chan Kwong Yu Gordon and others

A catalyst for the generation of hydrogen from a small organic molecule comprises a tertiary metal composition where: the first metal is either pt or ru; the second metal is at least one of pt, ru, au, pd, rh, ir, os, and/or re; and bi, primarily present in the form of an oxide or of a mixture of oxides and carbonates and in the +3 oxidation state. A portion of the first and/or second metal may be in the form of an oxide. The catalyst can be in the form of a nanoparticle and supported on an inert substrate, such as carbon. The catalyst can be used for dehydrogenation of formic acid or other small organic molecules in a liquid state at ambient pressures and at temperatures below the boiling point of the liquid. The liquid can be an aqueous solution of the small organic molecule.

 

Reagents for detection of hypochlorous acid

Year: 2011 / 2010 / 2009 / 2008

Area: Fluorescent probes

Inventor: Yang Dan and others

Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the hypochlorous acid probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening hypochlorous acid or compounds that can increase or decrease, directly or indirectly, the level of hypochlorous acid or hypochlorite in chemical and biological samples.

 

5-demethoxyfumagillol and derivatives thereof

Area: Fluorescent probes

Inventor: Yang Dan and others

Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities of the 5-demethoxyfumagillol and derivatives and methods of using same for treating diseases.

 

Fluorophore compounds

Year: 2011 / 2009

Area: Fluorescent probes

Inventor: Yang Dan and others

Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell, tissue, drug, hormone, nucleotide, nucleic acid, polysaccharide or lipid in living organisms. Specifically, the methods include the steps of contacting any of the fluorophore compounds, rhodol compounds and rhodamine compounds disclosed herein with the biological species to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening biological species.

 

Luminescence quenchers and fluorogenic probes for detection of reactive species

Year: 2011 / 2010 / 2009

Area: Fluorescent probes

Inventor: Yang Dan and others

Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the fluorogenic probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite or hypochlorite in chemical and biological samples.

 

Method of modulating membrane potential of a cell

Year: 2011 / 2009

Area: Healthcare

Inventor: Yang Dan and others

Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and /or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

 

Native chemical ligation at serine and threonine sites

Area: Healthcare

Inventor: Li Xuechen and others

A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (Fig. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond.

 

Nitridoosmium(VI) complexes for treatment of cancer

Area: Healthcare

Inventor: Che Chi Ming and others

The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.

 

Pharmaceutical compositions for induction of apoptosis of cancer cells and inhibition of reverse transcriptase of human immunodeficiency virus-1

Area: Healthcare

Inventor: Che Chi Ming and others

Disclosed is the use of gold (III) complexes of porphyrins, Schiff-bases, bis(pyridyl)carboxamides and bis(pyridyl)sulfonamides as anti-tumor and anti-HIV agents.

 

5-demethoxyfumagillol and derivatives thereof

Year: 2011 / 2009

Area: Healthcare

Inventor: Yang Dan and others

Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities of the 5-demethoxyfumagillol and derivatives and methods of using same for treating diseases.

 

Hydroxy-substituted gold (iii) porphyrin complexes as histone deacetylase inhibitors

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of or a pharmaceutically acceptable salt thereof, wherein: -R is selected from the group consisting of -OH, -CH2OH, C2H4OH, -C3H6OH or -C4H8OH; and X is independently a pharmaceutically acceptable counter-ion.

 

Platinum (II) isoqulinoline-pyridine-benzene based complexes, methods for making same, and organic light-emitting diodes including such complexes

Year: 2011 / 2010

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

This invention provides a class of organometallic complexes comprising a tridentate isoquinoline-pyridine-benzene based ligand, a mono-dentate ligand and a platinum (II) center which show high emission quantum efficiency and good thermal stability. This invention also discloses organometallic complexes in organic light-emitting diode (OLED) including them.

 

2010

Thiourea compositions and uses thereof

Year: 2010 / 2009 / 2007 / 2006 / 2005

Area: Catalysis

Inventor: Yang Dan and others

The invention provides N,N'-disubstituted monothiourea or bis-thiourea-Pd(0) complexes that are useful as catalysts for palladium-catalyzed Heck reaction of aryl iodides and bromides with olefins, and as catalysts for palladium catalyzed Suzuki reactions of organoboric compounds and aryl halides.

 

Lanthanide-porphyrin complexes as anti-tumor agents

Area: Healthcare

Inventor: Che Chi Ming and others

The present invention relates to lanthanide porphyrin complexes and their uses as anti-tumor agents. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.

 

Synthetic ion channels

Year: 2010 / 2009 / 2008

Area: Healthcare

Inventor: Yang Dan and others

Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.

 

Sensitive single-layer sensing device of covalently attached luminescent indicator on glass surface for measuring the concentration of analytes

Area: Optical sensors

Inventor: Yam Wing Wah Vivian and others

A sensing element which contains a single layer of luminescent indicator of ruthenium complexes covalently attached onto the glass surface is described. The system is capable of detecting analyte, for example, oxygen, concentration in gases or in dissolved condition in fluids by luminescence quenching of the said indicator to analyte. The sensitive single-layer system achieves reproducible and short response behavior.

 

Electroluminescent metallo-supramolecules with terpyridine-based groups

Year: 2010 / 2009 / 2007 / 2006 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Highly fluorescent metallo-supramolecules based on terpyridine-based monomers and transition metals have been obtained. These robust supramolecules provide high quantum yields with emissions from violet to blue, green or yellow color. They have emerged as promising emitters for polymeric light-emitting diodes (pleds) due to desirable properties such as high luminance, high purity, low cost, and good thermal stabilities. The supramolecule has molecular structure represented by the formula wherein m represents group ib, iib viia, viiia or lanthanide metals; r is independently in each occurrence and is selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, or recognized donor and acceptor groups; x is independently in each occurrence and is nitrogen or carbon atom; r is selected from alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, alkyl ketone, aryl ketone, heteroaryl ketone, alkylester, arylester, heteroarylester, alkylamide, arylamide, heteroarylamide, alkylthio, arylthio, fluoroalkyl, fluoroaryl, amine, imide, carboxylate, sulfonyl, alkyleneoxy, polyalkyleneoxy, or combination thereof; n is an integer of 1 to 100,000; z is a counter ion and is selected from the group of acetate, acetylacetonate, cyclohexanebutyrate, ethylhexanoate, halide, hexafluorophosphate, hexafluoroacetylacetonate, nitrate, perchlorate, phosphate, sulfate, tetrafluoroborate or fluoromethanesulfonate; y is an integer of 0 to 4.

 

Electroluminescent materials

Year: 2010 / 2009 / 2006 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Highly luminous, thermally stable and moisture-resistant light-emitting materials derived from quadridentate ONNO-type ligands and a Group 10 metal were employed as emissive dopants in organic light-emitting devices. The dopants have molecular structures represented by the formula I and II: wherein M represents Group 10 metal (including platinum) and R1-R14 are each independently selected from the group consisting of hydrogen; halogen; alkyl; substituted alkyl; aryl; substituted aryl, with substitutents selected from the group consisting of halogen, lower alkyl and recognized donor and acceptor groups.

 

Materials for electroluminescent devices

Year: 2010 / 2009 / 2007 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Materials containing one or more borazine rings are employed as materials for electroluminescent devices. The compounds have molecular structures represented by the following formula: in which R1-R6 are independently a metal; a whole or part of an optionally substituted borazine ring; hydrogen; halogen; hydroxyl; optionally substituted alkyl, cycloalkyl, aryl, acyl, alkoxy, acyloxy, amino, acylamino, aralkyl, cyano, carboxyl, thio, vinyl, styryl, aminocarbonyl, carbamoyl, aryloxycarbonyl, phenoxycarbonyl, or alkoxycarbonyl, as well as recognized donor and acceptor groups. The compounds have high thermal stability as well as hole and electron mobilities.

 

Organic light-emitting devices

Year: 2010 / 2009 / 2007 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Disclosed Are Electrophosphorescent Organic Metal Complexes With Formula (I) Or (Ii), Of Either Geometrical Isomers, Comprising Two Bidentate Nn-Type Ligandsor A Tetradentate Nnnn-Type Ligand, And A Transition Metal. These Electrophosphorescent Materials Are Valuable To The Application In Organic Light-Emitting Devices (Oleds), Including Red-, Orange-, Or Yellow-Light Oleds.

 

Organometallic light-emitting material

Year: 2010 / 2009 / 2007 / 2006 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Disclosed herein are novel light-emitting materials of Formula I and II below. These new complexes are synthesized and found to be sufficiently stable to allow sublimation and vacuum deposition. These new emitters are electrophosphorescent and can be used in organic light-emitting devices (OLEDs) for device elements capable of emitting light of color ranging from orange to red with high-efficiency and high-brightness. wherein E=Group 16 elements (including sulphur); M=Group 10 metal (including platinum); R1-R14 are each independently selected from the group consisting of hydrogen; halogen; alkyl; substituted alkyl; aryl; substituted aryl, with substituents selected from the group consisting of halogen, lower alkyl and recognized donor and acceptor groups.; R1 can also be selected from (C[identical to]C)nR15, where (C[identical to]C) represents a carbon-carbon triple bond (acetylide group), n is selected from 1 to 10, and R15 is selected from alkyl, aryl, substituted aryl, and tri(alkyl)silyl.

 

Materials for electroluminescent devices

Year: 2010 / 2009 / 2007 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Materials containing one or more borazine rings are employed as materials for electroluminescent devices. The compounds have molecular structures represented by the following formula: in which R1-R6 are independently a metal; a whole or part of an optionally substituted borazine ring; hydrogen; halogen; hydroxyl; optionally substituted alkyl, cycloalkyl, aryl, acyl, alkoxy, acyloxy, amino, acylamino, aralkyl, cyano, carboxyl, thio, vinyl, styryl, aminocarbonyl, carbamoyl, aryloxycarbonyl, phenoxycarbonyl, or alkoxycarbonyl, as well as recognized donor and acceptor groups. The compounds have high thermal stability as well as hole and electron mobilities.

 

2009

Supported ruthenium nanoparticle catalyst for cis -dihydroxylation and oxidative cleavage of alkenes

Year: 2009 / 2008 / 2007 / 2006 / 2005

Area: Catalysis

Inventor: Che Chi Ming and others

The present invention relates to the use of nanosized metal particles (e.g., ruthenium) grafted on inert solid support for oxidation of alkenes. The supported metal catalyst can effect cis-dihydroxylation and oxidative cleavage of alkenes to give the respective cis-diols and carbonyl products.

 

Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrin catalysts

Year: 2009 / 2007 / 2005

Area: Catalysis

Inventor: Che Chi Ming and others

Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrins as catalyst provides high trans-selectivities (i.e., trans-:cis-epoxide ratio). A diversity of cycloalkenes bearing different allylic substituents are shown to be efficiently epoxidized to afford the corresponding trans-epoxides with excellent trans-selectivities (up to >98%) and good yields (up to 99%). Acyclic allylic alkenes bearing different allylic substituents are efficiently epoxidized to afford the corresponding erythro-epoxides with good erythro-selectivities. The metalloporphyrin-catalyzed reactions exhibit up to 20 times higher trans-selectivities than the conventional method using m-chloroperoxybenzoic acid as oxidant.

 

Anti-Cancer phosphine containing [Auiiim(Cnc)Ml]N+ complexes and derivatives thereof and methods for treating cancer using such compositions

Year: 2009 / 2008

Area: Healthcare

Inventor: Che Chi Ming and others

Gold(III) phosphine complexes [Au.sub.m(CNC).sub.mL].sup.n+ (where HCNCH=2,6-diphenylpyridine) and their use as anti-tumor agents are disclosed. Notable results for the appearance of new potential anti-tumor application of these gold(III) complexes are reported. The described complexes show promising cytotoxic properties toward cancer cells in both in vitro and in vivo studies.

 

Diazene-bridged crown ether lithium compounds and methods for their use

Year: 2009 / 2008 / 2007 / 2006

Area: Healthcare

Inventor: Che Chi Ming and others

This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.

 

Di(Amido-Substituted) heteroarene compounds as osteoblastogenesis agents

Year: 2009 / 2007

Area: Healthcare

Inventor: Che Chi Ming and others

Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.

 

2008

High-Voltage dual electrolyte electrochemical power sources

Area: Energy

Inventor: Chan Kwong Yu Gorden and others

An electrochemical device such as a battery and a fuel cell having two electrolytes between the anode and the cathode. The electrochemical device is preferably arranged with an alkaline electrolyte in contact with the anode and an acidic electrolyte in contact with the cathode. The electrolytes are separated by a bipolar membrane that preferably also provides ionic conductivity between the two electrolytes and also generates a supply of protons and hydroxide anions. The electrochemical device achieves fifty percent higher operating voltage and power compared to fuel cells with a single electrolyte.

 

Reagents for highly specific detection of peroxynitrite

Year: 2008 / 2007

Area: Fluorescent probes

Inventor: Yang Dan and others

This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.

 

Methods and apparatus for oxidation of glucose molecules

Year:  2008 / 2007 / 2005

Area: Fuel cells 

Inventor: Chan Kwong Yu Gordon and others

A catalyst comprising pt-co alloy, or pt-co-sn alloy or pt-comon mixed metal oxides is disclosed to be used as a catalyst for the direct electrochemical oxidation of glucose or other simple sugars and carbohydrates at room temperature. The catalyst can be supported on metal electrodes, graphite electrodes, porous carbon electrodes, or gas diffusion electrodes. An electrode containing this catalyst will be used as the key component in a direct glucose-air fuel cell operating in alkaline media with a good room temperature performance. This catalyst can also be applied as a key electrode material in a glucose sensor to detect glucose concentration in neutral or alkaline medium. The preparation method of the catalyst, optimum composition, and results of glucose sensor and glucose fuel cell applications are disclosed.

 

Polymer composite membrane and method of making the same

Year: 2008 / 2006

Area: Fuel cells 

Inventor: Chan Kwong Yu Gordon and others

The present invention provides a polymer composite membrane having a polymer membrane and a poly(furfuryl alcohol) filling internal pores of the polymer membrane. The polymer composite membrane can have a high proton conductivity and/or a reduced methanol permeability and can be used in fuel cells, electrochemical sensor, and the like. The present invention also provides a method of making a polymer composite membrane, by providing a perfluorosulfonic polymer member, subjecting the perfluorosulfonic polymer member to a furan-based monomer, and polymerizing the furan-based monomer to obtain a polymer composite membrane having a high proton conductivity and/or a reduced methanol permeability.

 

Materials for organic thin film transistors

Year: 2008 / 2007

Area: Organic electronics

Inventor: Che Chi Ming and others

The invention provides organic thin film transistors including quinacridone derivatives with formula (I). These OTFTs are useful in making flat panel displays, photovoltaic devices and sensors. In the present invention, the disclosed quinacridone derivatives exhibit as p-type organic semiconductors in OTFTs.

 

System and method for producing light with organic light-emitting devices

Year: 2008 / 2005

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

Disclosed are emissive materials of formula (i) or (ii), comprising two bidentate no-type ligands, or a tetradentate noon-type ligand, and a transition metal. The emissive materials are useful as electrophosphorescent emitters in organic light-emitting devices. Also disclosed are methods for preparing organic light-emitting diodes comprising these emissive materials, and the use of such diodes as white and yellow organic light-emitting devices.

 

Device for and method of generating ozone

Year: 2008 / 2006 / 2005

Area: Water treatment

Inventor: Chan Kwong Yu Godwin

The invention can provide an electrode member having a substrate member and a coating member. The substrate member can be made of a material selected from the group consisting of titanium, gold coated titanium and other inert conducting materials. The coating member can have a tin dioxide modified by antimony. The electrode member of the present invention can be used for direct generation of ozone in water or through water into a gaseous state.

 

2006

Intramolecular Amidation Of Sulfamates Catalyzed By Metalloporphyrins

Area: Catalysis

Inventor: Che Chi Ming and others

An intramolecular amidation processes for substrates such as sulfamates using chiral and non-chiral metalloporphyrin complexes which can maximize catalytic activity, enhance efficiency, stereoselectivity and speed of amidation reactions is described. The chiral metalloporphyrin catalyzed amidation of sulfamates exhibits excellent cis-selectivity, affording cyclic sulfamidates with high enantiomeric excess values.

 

Luminescent sensory material for organic-halogen compounds, and methods and apparatus utilizing such

Area: Organic light-emitting devices

Inventor: Che Chi Ming and others

A luminescent sensory material for the detection of the presence of organo-halogen compounds is described. This material is based on a platinum chromophore functionalized with pyridylacetylide ligands, as shown in formulae i and ii below. These complexes exhibit positive luminescence upon exposure to the vapors of organ-halogen compounds like ch2cl2 or chcl3 with high selectivity over non-chlorinated common organic vapors. Direct relationships between vapor concentration and luminescence intensity are established using thin films prepared from these complexes.

 

2005

Method for synthesizing 5 beta, 6 beta-Epoxides of steroids by a highly beta-selective epoxidation of deltadelta5-unsaturated steroids catalyzed by ketones

Area: Catalysis

Inventor: Yang Dan and others

A general, efficient, and environmentally friendly method is provided for producing mostly beta-epoxides of delta<5>-unsaturated steroids using certain ketones as the catalyst along with an oxidizing agent, or by using certain dioxiranes. In another aspect of the invention, a method is provided for producing mostly 5beta,6beta-epoxides of steroids from delta<5>-unsaturated steroids having a substituent at the 3alpha-position by an epoxidation reaction using a ketone along with an oxidizing agent under conditions effective to generate epoxides, or using a dioxirane under conditions effective to generate epoxides.; a whole range of delta<5>-unsaturated steroids, bearing different functional groups such as hydroxy, carbonyl, acetyl or ketal group as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5beta,6beta-epoxides with excellent beta-selectivities and high yields.

 

Gold (III) complexes as anti-tumor and anti-HIV agents

Area: Healthcare

Inventor: Che Chi Ming and others

Disclosed is the use of gold (III) complexes of porphyrins, Schiff-bases, bis(pyridyl)carboxamides and bis(pyridyl)sulfonamides as anti-tumor and anti-HIV agents.