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Metal Complexes in Medicinal Chemistry
| Date | 04 Dec 2025 |
| Time | 6:15 pm - 7:15 pm (HKT) |
| Venue | Lecture Theatre P1, Chong Yuet Ming Chemistry Building |
| Speaker | Prof. Gilles Gasser |
| Institution | Chimie ParisTech - PSL University |
Title:
Metal Complexes in Medicinal Chemistry
Schedule:
Date: 4thDecember, 2025 (Thursday)
Time: 6:15 - 7:15 pm (HKT)
Venue: Lecture Theatre P1, Chong Yuet Ming Chemistry Building
Speaker:
Prof. Gilles Gasser
Chimie ParisTech - PSL University
Biography
Gilles Gasser started his independent scientific career at the University of Zurich (Switzerland) in 2010 before moving to Chimie ParisTech, PSL University in 2016 to take a PSL Chair of Excellence. Gilles was the recipient of several fellowships and awards including the Alfred Werner Award from the Swiss Chemical Society, an ERC Consolidator Grant and Proof of Concept, the European BioInorganic Chemistry (EuroBIC), the Pierre Fabre Award for therapeutic innovation from the French Société de Chimie Thérapeutique, the Coordination Chemistry Prize from the French Chemical Society (Senior Level) and recently the Seqens Prize from the French Academy of Sciences for outstanding work in medicinal chemistry. Gilles’ research interests lay in the use of metal complexes in different areas of medicinal and biological chemistry.
Abstract
Metal complexes are currently playing a tremendous role in medicine.1,2 For example, the platinum complex cisplatin and its derivatives oxaliplatin and carboplatin are employed in more than 50% of the treatment regimes for patients suffering from cancer!
Over the last years, our research group focused its attention on the development of novel metal complexes as imaging and therapeutic agents against cancer and parasitic diseases.3-7 During this talk, we will present our latest results, including in vivo results, on these topics.
References
(1) Boros, E.; Dyson, P. J.; Gasser , G. Classification of Metal-based Drugs According to Their Mechanisms of Action. Chem 2020, 6, 41-60.
(2) Patra, M.; Gasser , G. The Medicinal Chemistry of Ferrocene and its Derivatives. Nature Rev. Chem. 2017, 1, 0066, and references therein.
(3) Černauskienė, I.; Izquierdo-García, E.; Keller, S.; Betts, H.; Cariou, K.; Marchán, V.; Gasser, G.; Bernardes, G. J. L. A Cathepsin B-Triggered CO-Releasing Molecule with a Non-Toxic Metal Core for Targeted Tumor Delivery. Angew. Chem. Int. Ed., DOI:https://doi.org/10.1002/anie.202513808 https://doi.org/10.1002/anie.202513808, e13808.
(4) Figueiredo, F.; Madec, H.; Mesdom, P.; Salluce, G.; Tigherghar, Y.; Cariou, K.; Roland, S.; Sollogoub, M.; Gasser, G. Encapsulating NHC–capped copper(i) complexes inside cyclodextrin for catalysis in living cells. Chem. Sci. 2025, 16 (42), 19727-19736.
(5) Flamme, M.; Niogret, G.; McKenzie, L.; Akhtar, U.; Levi-Acobas, F.; Gandioso, A.; Clarke, E.; Bizat, P. N.; Connor, M.; Hamon, M. A.et al. Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia. J. Am. Chem. Soc. 2025, DOI:10.1021/jacs.5c13224 10.1021/jacs.5c13224, https://doi.org/10.1021/jacs.1025c13224.
(6) Mani, A.; Feng, T.; Gandioso, A.; Vinck, R.; Notaro, A.; Gourdon, L.; Burckel, P.; Saubaméa, B.; Blacque, O.; Cariou, K.et al. Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared. Angew. Chem. Int. Ed. 2023, 62, e202218347.
(7) Redrado, M.; Acharya, S.; Mesdom, P.; Babu, T.; Southwell, J. W.; Oliveira, L. S.; Hidalgo, S.; Arnoux, P.; Frochot, C.; Gibson, D.et al. A Triple Threat Against Ovarian Cancer: Os(II)-Pt(IV)-Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction. Angew. Chem. Int. Ed., DOI:https://doi.org/10.1002/anie.202518623 https://doi.org/10.1002/anie.202518623, e202518623.
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