Hydrogen Bonds as Directing Elements in Enantioselective Reactions

 

Date: 18^th November, 2024 (Monday)

Time: 10 - 11 am (HKT)

Venue: Lecture Theatre P2, Chong Yuet Ming Physics Building

Prof. Thorsten Bach

 

Department Chemie and Catalyisis Research Center (CRC)

School of Natural Sciences

Technische Universität München

Hydrogen bonds belong to the most important non-covalent interactions and are perfectly suited to position a given substrate in a defined chiral environment. Our group has discovered and continues to explore enantio- and site-selective catalytic reactions based on hydrogen bonding. The talk will revolve around the use of chiral tricyclic lactams as tools in three different settings: (1) Catalytic enantioselective photochemical reactions via energy transfer,^[1] (2) photochemical deracemization reactions,^[2] and (3) C-H activation reactions mediated by transition metal complexes.^[3]

[1] J. Großkopf, T. Kratz, T. Rigotti, T. Bach, Chem. Rev. 2022, 122, 1626-1653.

[2] A. Hölzl-Hobmeier, A. Bauer, A. V. Silva, S. M. Huber, C. Bannwarth, T. Bach, Nature 2018, 564, 240-243.

[3] Recent example: H. Ahmed, B. Ghosh, S. Breitenlechner, M. Feßner, C. Merten, T. Bach, Angew. Chem. Int. Ed. 2024, 63, e202407003.