Events
Date 21 Aug 2024
Time 4:30 pm - 5:30 pm (HKT)
Venue Lecture Theatre P2, Chong Yuet Ming Physics Building
Speaker Prof. Yang LI
Institution College of Chemistry and Chemical Engineering
Chongqing University
Self Photos / Files - Prof. Yang Li Seminar Poster
 
Title:
A Step Beyond the Boundary of Traditional Aryne Chemistry
 
Schedule:
Date: 21st August, 2024 (Wednesday)
Time: 4:30 - 5:30 pm (HKT)
Venue: Lecture Theatre P2, Chong Yuet Ming Physics Building
Speaker:
Prof. Yang LI
 
College of Chemistry and Chemical Engineering
Chongqing University
 
Abstract:
Polysubstituted arenes broadly exist in numerous natural products, drug molecules, and organic functional materials. How to quickly construct those structural motifs continues to be one of the themes in organic chemistry. Although benzyne intermediate can readily assemble vicinal difunctionalized arenes, it has been restricted to realize multifunctionalization with respect to this highly active yet fleeting species. Our research focuses on the ways to break the boundary of traditional aryne chemistry. In order to expeditiously prepare various polysubstituted arenes via aryne intermediates, we developed two strategies: 1,2-benzdiyne (namely domino aryne) chemistry and tandem simple benzyne reaction/rearrangement. Meanwhile, we are interested in the discovery of new reaction maneuvers in aryne chemistry. Along with the development of our aryne multifunctionalization systems, bioactive molecules are prepared.
 
Representative Publications:

1. He, J.; Qiu, D.; Li, Y.* “Strategies toward Aryne Multifunctionalization via 1,2-Benzdiyne and Benzyne” Acc. Chem. Res. 2020, 53, 508-519.

2. Shi, J.; Qiu, D.; Wang, J.; Xu, H.; Li, Y.* “Domino Aryne Precursor: Efficient Construction of 2,4-Disubstituted Benzothiazoles” J. Am. Chem. Soc. 2015, 137, 5670-5673.

3. Li, Y.; Qiu, D.; Gu, R.; Wang, J.; Shi, J.; Li, Y.* “Aryne 1,2,3-Trifunctionalization with Aryl Allyl Sulfoxides” J. Am. Chem. Soc. 2016, 138, 10814-10817.

4. Xu, H.; He, J.; Shi, J.; Tan, L.; Qiu, D.; Luo, X.; Li, Y.* “Domino Aryne Annulation via Nucleophilic-Ene Process” J. Am. Chem. Soc. 2018, 140, 3555-3559.

5. Qiu, D.; Shi, J.; Guo, Q.; Xu, Q.; Li, B.; Li, Y.* “Cyclohexenynone Precursors: Preparation via Oxidative Dearomatization Strategy and Reactivity” J. Am. Chem. Soc. 2018, 140, 13214-13218.

 
- - ALL ARE WELCOME --