Enantioconvergent Redox-Neutral Functionalization of Alcohols via Borrowing Hydrogen Catalysis

Enantioconvergent Redox-Neutral Functionalization of Alcohols via Borrowing Hydrogen Catalysis

Date: 19^th June, 2024 (Wednesday)

Time: 4:30 - 5:30 (HKT)

 

Venue: Lecture Theatre P2, Chong Yuet Ming Physics Building

 

Prof. Yu ZHAO

Department of Chemistry

National University of Singapore

 

The development of economical and selective catalytic methods is of significant importance for the promotion of sustainable chemical synthesis. My group at National University of Singapore has focused on the identification of catalytic enantioselective redox-neutral transformations that directly convert feedstock materials to valuable chiral entities with wide application in organic synthesis. In particular, we have achieved a series of direct stereoconvergent “substitution” of readily available racemic alcohols via borrowing hydrogen catalysis for economical access to chiral amines, N-heterocycles, alcohols and ketones, etc. Recent progress in identifying new catalytic processes along these lines will be discussed in details in this presentation.