Confinement Controlled Electrochemistry for Single Entity Analysis

Title:

Confinement Controlled Electrochemistry for Single Entity Analysis

Schedule:

Date: 22^nd May, 2024 (Wednesday)

Time: 3:30 - 4:30 pm (HKT)

Venue: Lecture Theatre P1, Chong Yuet Ming Chemistry Building

Speaker:

Biography:

Yi-Tao Long, Professor of Analytical Chemistry and Director of Molecular Sensing and Imaging Centre at Nanjing University. He earned B.Sc. (1989) from Shangdong University and PhD (1998) from Nanjing University. After 2-year postdoctoral study at Heidelberg University, he worked as a Research Associate at University of Saskatchewan and University of Alberta, Canada, and the Associate Specialist at University of California, Berkeley. He returned to Nanjing University in 2019 after worked 12 year as full Professor at East China University of Science and Technology. His main research focuses on the electrochemistry at nanoconfinement which involves nanopore electrochemistry for single-molecule analysis, nanospectroelectrochemistry for biointerphase and the nanoelectrochemical instruments for life science. Professor Long has published over 400 peer-reviewed scientific journal papers, 5 books/chapters and 4 PCT patents. He currently serves as Associate Editor for Chemical Science, and Editorial Board/Advisory Board Member of Chemical Reviews, ChemElectroChem, Research, Theranostics and Microchimica Acta. He is the Fellow of the Royal Society Chemistry (RSC), Fellow of the Chinese Chemical Society (CCS) and Fellow of International Society of Electrochemistry (ISE), honorary visiting professor at University of Birmingham (2014-2020), visiting professor at University of Bath (2011-2016). He has received the CCS Liang Shuquan Award for Fundamental Research in Analytical Chemistry (2018), and RSC Faraday Medal (2023). He is co-chairs of a series of RSC Faraday Discussions on Electrochemistry (2018, 2021, and 2024).

Abstract:

Single-entity electrochemistry (SEE) describes a recent trend in state-of-the-art electrochemistry applied to the investigation of individuals at a time. SEE is particularly appealing as it integrates different branches of modern electrochemistry and combines diverse fundamental approaches and techniques towards the ultimate limits of measurements. It provides powerful means to measure single cells, single particles, and even single molecules at the nanoscale through various well-defined interfaces. The confinement-controlled interface significantly enhances electrical, and electromagnetic characteristics for electrochemical analysis, thereby greatly affecting the assay limitation and selectivity of single-entity measurement. Herein, we demonstrate how to achieve controllable nanoelectrochemistry through micro/nano confined electrode surfaces and protein nanopore confined single molecule interfaces. The presentation provides a foundational comprehension of how dynamic interactions regulate the characteristics of the electrochemical interface, thus affecting the stochastic and discrete electrochemical responses of individual entities within nanoconfinement. Stochastic collision electrochemistry and nanopore electrochemistry, exemplified in this presentation, are employed to reveal how these interactions alter the transient charge transfer and mass transport at the microscopic level. Additionally, the discussion addresses further challenges and opportunities in single-entity electrochemistry (SEE), spanning from the design of sensing interfaces to hybrid spectroelectrochemical methods, theoretical models, and advanced data processing.

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