Metal-based Anticancer Drugs for Selective Tumour-Targeting

Date	20 Mar 2024
Time	11:00 am - 12:00 noon (HKT)
Venue	Lecture Theatre T6, Meng Wah Complex
Speaker	Prof. Dr. Evamarie Hey-Hawkins
Institution	Leipzig University, Faculty of Chemistry and Mineralogy, Central for Biotechnology and Biomedicine (BBZ), Institute of Bioanalytical Chemistry

Title:

Metal-based Anticancer Drugs for Selective Tumour-Targeting

Schedule:

Date: 20^th March, 2024 (Wednesday)

Time: 11 am - 12 noon (HKT)

Venue: Lecture Theatre T6, Meng Wah Complex

Speaker:

Prof. Dr. Evamarie Hey-Hawkins

Leipzig University, Faculty of Chemistry and Mineralogy

Central for Biotechnology and Biomedicine (BBZ),

Institute of Bioanalytical Chemistry

Abstract:

Cancer is among the leading causes of death worldwide. Chemotherapy, one of the most common treatments, is often accompanied by significant side effects, and tumour resistance to certain chemotherapeutic drugs is another major problem. Therefore, the search for new antitumour agents and new therapy methods is important.

The Hey-Hawkins group designs metal-based chemotherapeutic agents which, when combined with biologically active compounds or drugs already used in cancer therapy, have a higher selectivity and activity towards tumour cells (hybrid compounds, dual therapy). Furthermore, these drug conjugates are loaded into mesoporous silica SBA-15 with the aim to utilise the passive enhanced permeability and retention (EPR) effect of nanoparticles for accumulation in tumour tissues.

References

I. Predarska, M. Saoud, I. Morgan, T. Eichhorn, G. N. Kaluđerović, E. Hey-Hawkins, Dalton Trans. 51 (2022) 857-869.

I. Predarska, M. Saoud, D. Drača, I. Morgan, T. Komazec, T. Eichhorn, E. Mihajlovic, D. Dunđerović, S. Mijatović, D. Maksimović-Ivanić, E. Hey-Hawkins, G. N. Kaluđerović, Nanomaterials 12 (2022) 3767 (23 pages).

I. Predarska, M. Saoud, V. Cepus, E. Hey-Hawkins, G. N. Kaluđerović, Adv. Therap. 6 (2023) 2300062 (12 pages).

D. Drača, M. Marković, M. Gozzi, S. Mijatović, D. Maksimović-Ivanić, E. Hey-Hawkins, Molecules 26 (2021) 3801 (10 pages).

M. Gozzi, B. Murganić, D. Drača, J. Popp, P. Coburger, D. Maksimović-Ivanić, S. Mijatović, E. HeyHawkins, ChemMedChem 14 (2019) 2061-2074.

B. Schwarze, S. Jelača, L. Welcke, D. Maksimović-Ivanić, S. Mijatović, E. Hey-Hawkins, ChemMedChem 14 (2019) 2075-2083.

W. Neumann, B. C. Crews, M. B. Sárosi, C. M. Daniel, K. Ghebreselasie, M. S. Scholz, L. J. Marnett, E. Hey-Hawkins, ChemMedChem 10 (2015) 183-192.

W. Neumann, B. C. Crews, L. J. Marnett, E. Hey-Hawkins, ChemMedChem 9 (2014) 1150-1153.

- ALL ARE WELCOME -