Transition Metal Catalyzed Cycloaddition Reactions to Synthesize Seven- and Eight-Membered Rings

Title:

Transition Metal Catalyzed Cycloaddition Reactions to Synthesize Seven- and Eight-Membered Rings

Schedule:

Date: 28^th March, 2024 (Thursday)

Time: 5 - 6 pm (HKT)

Venue: Lecture Theatre P2, Chong Yuet Ming Physics Building

Speaker:

Prof. Zhixiang Yu

Department of Chemistry and Molecular Engineering,

Peking University

Abstract:

Many natural products and pharmaceutical compounds have complex skeletons. One of the major challenges in synthesizing these molecules is how to efficiently build the complex skeletons within. Even though there are many powerful reactions (such as Diels-Alder reaction, Pauson-Khand reaction, ring-closing metathesis reaction) for accessing different ring structures, new ring formations reactions, especially those complementing or surpassing previous ones, are in high demand. To solve this challenge, my group has been endeavoring to develop new ring formation reactions. Since 2004, a dozen of ring formation reactions has been developed by us. Application of these ring formation reactions in total synthesis of natural products has been achieved by us and other leading chemists. In this 50-minute seminar, I will discuss the development and mechanistic understanding of several transition metal catalyzed cycloadditions for constructing synthetically difficult seven- and eight-membered rings, together with application of our [5+2+1] reaction in the synthesis of natural products.

- ALL ARE WELCOME -