Covalent-Organic Pillars: A Family of Nanotubular Hosts with Deep Cavities

Title:

Covalent-Organic Pillars: A Family of Nanotubular Hosts with Deep Cavities

Schedule:

Date: 20^th February, 2024 (Tuesday)

Time: 5 - 6 pm (HKT) 

Venue: Lecture Theatre P2, Chong Yuet Ming Physics Building

Speaker:

Prof. Andrew C.-H. Sue

College of Chemistry and Chemical Engineering

Xiamen University

Biography:

Andrew C.-H. Sue is now a professor at the College of Chemistry & Chemical Engineering at Xiamen University in China. He earned his B.Sc. and M.Sc. degrees from National Chiao-Tung University in Taiwan in 2002 and 2004, respectively. Later, he received his Ph.D. degree from the University of California Los Angeles in 2011, working under the tutelage of Sir Fraser Stoddart. Andrew then conducted postdoctoral research with Professor Omar Yaghi at the University of California Berkeley, before embarking on his independent career in 2015 at Tianjin University. In 2021 he joined Xiamen University, where he currently leads his research group in the field of supramolecular chemistry, exploring diverse aspects of macrocyclic compounds, deep cavity cavitands, coordination-driven assembly, and dynamic stereochemistry.

Abstract:

Despite significant strides made in supramolecular chemistry, the availability of artificial macrocyclic hosts with deep cavities remains limited. One promising strategy to address this challenge involves integrating multiple macrocycles to expand their cavities, as demonstrated by the utilization of calixarenes in constructing various molecular capsules, cages, and frameworks. Moreover, pillararenes, characterized by their unique straight pillar-like structure, are ideal building blocks for creating elongated and narrow nanotubular hosts. This seminar will highlight the design and synthesis of a series of single-molecule nanotubular hosts, namely covalent-organic pillars (COPs). These COPs are crafted by stacking aldehyde functionalized rim-differentiated pillar[5]arene rings with various diamine linkers through dynamic covalent imine condensation reactions. Notably, these COPs possess deep cavities exceeding 2 nm in length and 4.7 Å in width, exhibiting strong affinities for linear guest molecules with complementary dimensions and electronic densities.

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