Metalloenzmes - from mechanisms to medicines

Title:

Metalloenzmes- from mechanisms to medicines

Schedule:

Date: 31^st October, 2023 (Tuesday)

Time: 5:30 - 6:30 pm (HKT)

Venue: Lecture Theatre P2, Chong Yuet Ming Physics Building

Speaker:

Prof. Chris Schofield

Department of Chemistry

University of Oxford

Biography:

Chris Schofield studied for an undergraduate degree in chemistry at the University of Manchester Institute of Science and Technology. He moved to Oxford for DPhil studies with Jack Baldwin on the synthesis and biosynthesis of antibiotics. He subsequently became a Departmental Demonstrator in the Dyson Perrins Laboratory, and in 1990 Lecturer in Chemistry and Fellow of Hertford College. In 1998 he became Professor of Chemistry and he served as Head of Organic Chemistry from 2011 to 2021. He is a Fellow of the Royal Society and Head of Chemistry at the Ineos Oxford Institute for Antimicrobial Research.

His research group works at the interface of chemistry, biology and medicine. His work has opened up new fields in antibiotic research, oxygen sensing and gene regulation in organisms ranging from bacteria to plants and animals. His work has identified new opportunities for medicinal intervention that are being pursued by numerous academic and commercial laboratories.

Abstract:

The lecture will describe how mechanistic studies on how penicillins and related antibiotics are made and degraded by metalloenzymes has opened new avenues for basic research and medicinal chemistry.

- ALL ARE WELCOME -