Recent Publications
A soluble iron(ii)-phthalocyanine-catalyzed intramolecular C(sp3)–H amination with alkyl azides
T. You, S.H. Zeng, J. Fan, L. Wu, F. Kang, Y. Liu, C.M. Che
Chem. Commun. 2021,57, 10711 (Selected as Cover)
Towards multistate multimode landscapes in singlet fission of pentacene: the dual role of charge-transfer states
R. Walia, Z. Deng, J. Yang
Chem. Sci. 2021 DOI: 10.1039/d1sc01703a
Steering Electron‐Hole Migration Pathways using Oxygen Vacancies in Tungsten Oxides to Enhance their Photocatalytic Oxygen Evolution Performance
Z. Wei, W. Wang, W. Li, X. Bai, J. Zhao, E.C.M. Tse*, D. L. Phillips*, Y. Zhu*
Angew. Chem. Int. Ed. 2021, 60, 8236 DOI:10.1002/anie.202016170
Ferrocene-Based Metal–Organic Framework Nanosheets as a Robust Oxygen Evolution Catalyst
J. Liang, X. Gao, B. Guo, Y. Ding, J. Yan, Z. Guo, E.C.M. Tse*, J. Liu*
Angew. Chem. Int. Ed. 2021, 60, 12770 DOI:10.1002/anie.202101878
A Molecular Transformer: A π-Conjugated Macrocycle as an Adaptable Host
J. Wang, Y.-Y. Ju, K.-H. Low, Y.-Z. Tan, J. Liu*
Angew. Chem. Int. Ed. 2021, 60, 11814 DOI: 10.1002/anie.202102637
Defective Nanographenes Containing Seven-Five-Seven (7-5-7) Membered Rings
Y. Fei, Y. Fu, X. Bai, L. Du, Z. Li, H. Komber, K.-H. Low, S. Zhou, D. L. Phillips, X. Feng, J. Liu*
J. Am. Chem. Soc. 2021, 143, 2353 DOI: 10.1021/jacs.0c12116
Bio-adhesive Nanoporous Module: Toward Autonomous Gating
H. Jo, T. Kitao, A. Kimura, Y. Itoh, T. Aida*, K. Okuro*
Angew. Chem. Int. Ed. 2021, 60, 8932 DOI: 10.1002/anie.202017117
Total synthesis of mannopeptimycin via chemical ligation cyclization
J. Wang, D. Lin, M. Liu, H. Liu, Li, X.*
J. Am. Chem. Soc. 2021. 143, 12784 DOI: 10.1021/jacs.1c05922
Chemical Synthesis and Biological Evaluation of Adiponectin Collagenous Domain Glycoforms
H. Wu, Y. Zhang, Y. Li, J. Xu, Y. Wang*, X. Li*
J. Am. Chem. Soc. 2021, 143, 7808 DOI: 10.1021/jacs.1c02382
Revealing generation, migration and dissociation of electron−hole pairs and current emergence in an organic photovoltaic cell
Z. Xu, Y. Zhou, C.Y. Yam, T. Frauenheim, C. Lienau, G.H. Chen*
Sci. Adv. 2021, 7, eabf7672 DOI: 10.1126/sciadv.abf7672
Rapid Broad Spectrum Detection of Carbapenemases with a Dual Fluorogenic-Colorimetric Probe
C.W. Ma, K.K.H. Ng, B.H.C. Yam, P.L. Ho, R.Y.T. Kao, D. Yang*
J. Am. Chem. Soc. 2021, 18, 6886 DOI: 10.1021/jacs.1c00462
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
H.B. Wang, M.J. Wang, X.H. Xu, P. Gao, Z.L. Xu, Q. Zhang, H.Y. Li, A.X. Yan, R.Y.T. Kao, H.Z. Sun*
Nat. Commun. 2021, 12, 3331 DOI: 10.1038/s41467-021-23659-y
Photoinduced Hydroarylation and Cyclization of Alkenes with Luminescent Platinum(II) Complexes
H. Cheng, T.L. Lam, Y. Liu, Z. Tang, C.M. Che*
Angew.Chem. Int. Ed. 2021, 60, 1383-1389 DOI: 10.1002/anie.202011841
C−H Activation by an Iron-Nitrido Bis-Pocket Porphyrin Species
H.X. Wang, L. Wu, B. Zheng, L. Du, W.P. To, C.H. Ko, D. L. Phillips*, C.M. Che*
Angew.Chem. Int. Ed. 2021, 60,4796 DOI: 10.1002/anie.202014191
Aggregation and Supramolecular Self-Assembly of Low-Energy Red Luminescent Alkynylplatinum(II) Complexes for RNA Detection, Nucleolus Imaging, and RNA Synthesis Inhibitor Screening
A.S.Y. Law, L.C.C. Lee, K.K.W. Lo*, V.W.W. Yam*
J. Am. Chem. Soc. 2021, 143, 5396 DOI: 10.1021/jacs.0c13327
Dual Emissive Gold(I)–Sulfido Cluster Framework Capable of Benzene–Cyclohexane Separation in the Solid State Accompanied by Luminescence Color Changes
L.Y. Yao, V.W.W. Yam*
J. Am. Chem. Soc. 2021, 143, 2558 DOI: 10.1021/jacs.0c11891
Platinum(II)-Based Host–Guest Coordination-Driven Supramolecular Co-Assembly Assisted by Pt···Pt and π–π Stacking Interactions: A Dual-Selective Luminescence Sensor for Cations and Anions
Y.S. Wong, M. Ng, M.C.L. Yeung, V.W.W. Yam*
J. Am. Chem. Soc. 2021, 143, 973 DOI: 10.1021/jacs.0c11162
A tri-functional amino acid enables mapping of binding sites for posttranslational-modification-mediated protein-protein interactions
J. Lin, X. Bao*, X.D. Li*
Mol. Cell 2021, 81, 2669 DOI: 10.1016/j.molcel.2021.04.001
Strong metal–metal Pauli repulsion leads to repulsive metallophilicity in closed-shell d8 and d10 organometallic complexes
Q. Wan*, J. Yang*, W.P. To, C.M Che*
Proc. Natl. Acad. Sci. U.S.A. 2021, 118, e2019265118 DOI: 10.1073/pnas.2019265118
Geometrical manipulation of complex supramolecular tessellations by hierarchical assembly of amphiphilic platinum(II) complexes
J.K.L. Poon, Z. Chen, S.Y.L. Leung, M.Y. Leung, V.W.W. Yam*
Proc. Natl. Acad. Sci. U.S.A. 2021, 118, e2022829118
Catalytic reductive desymmetrization of malonic esters
P. Xu, Z. Huang*
Nat. Chem. 2021, 13, 634 DOI: 10.1038/s41557-021-00715-0
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells
Y. Huang, L. Meng, Q. Nie, Y. Zhou, L. Chen, S. Yang, Y. M. E. Fung, X. Li, C. Huang, Y. Cao,* Y. Li,* X. Li*
Nat. Chem. 2021, 13, 77 DOI: 10.1038/s41557-020-00605-x
Department News
- 04 May 2022 含腐蝕性化學物遇水升溫達90度 專家測試揭自熱食安隱憂
- 30 Mar 2022 Sharing from a Year 4 Chemistry Student (Jasmine Cheung) in Applying for PhD Programmes
- 19 Jan 2022 HKU scientists reveal orally administrated bismuth drug together with N-acetyl cysteine as a potential broad-spectrum anti-coronavirus cocktail therapy
- 19 Jan 2022 港大發現一「雞尾酒療法」可作潛在廣譜口服抗新冠特效藥
- 10 Jan 2022 港大研發新一代抗癌化合物 晚期癌症或有望變成慢性病
- 15 Dec 2021 Dr. Jian HE receives Croucher Innovation Awards 2021 in Croucher Foundation's ceremony
Recent Publications
A soluble iron(ii)-phthalocyanine-catalyzed intramolecular C(sp3)–H amination with alkyl azides
T. You, S.H. Zeng, J. Fan, L. Wu, F. Kang, Y. Liu, C.M. Che
Chem. Commun. 2021,57, 10711 (Selected as Cover)
Towards multistate multimode landscapes in singlet fission of pentacene: the dual role of charge-transfer states
R. Walia, Z. Deng, J. Yang
Chem. Sci. 2021 DOI: 10.1039/d1sc01703a
Steering Electron‐Hole Migration Pathways using Oxygen Vacancies in Tungsten Oxides to Enhance their Photocatalytic Oxygen Evolution Performance
Z. Wei, W. Wang, W. Li, X. Bai, J. Zhao, E.C.M. Tse*, D. L. Phillips*, Y. Zhu*
Angew. Chem. Int. Ed. 2021, 60, 8236 DOI:10.1002/anie.202016170
Ferrocene-Based Metal–Organic Framework Nanosheets as a Robust Oxygen Evolution Catalyst
J. Liang, X. Gao, B. Guo, Y. Ding, J. Yan, Z. Guo, E.C.M. Tse*, J. Liu*
Angew. Chem. Int. Ed. 2021, 60, 12770 DOI:10.1002/anie.202101878
A Molecular Transformer: A π-Conjugated Macrocycle as an Adaptable Host
J. Wang, Y.-Y. Ju, K.-H. Low, Y.-Z. Tan, J. Liu*
Angew. Chem. Int. Ed. 2021, 60, 11814 DOI: 10.1002/anie.202102637
Defective Nanographenes Containing Seven-Five-Seven (7-5-7) Membered Rings
Y. Fei, Y. Fu, X. Bai, L. Du, Z. Li, H. Komber, K.-H. Low, S. Zhou, D. L. Phillips, X. Feng, J. Liu*
J. Am. Chem. Soc. 2021, 143, 2353 DOI: 10.1021/jacs.0c12116
Bio-adhesive Nanoporous Module: Toward Autonomous Gating
H. Jo, T. Kitao, A. Kimura, Y. Itoh, T. Aida*, K. Okuro*
Angew. Chem. Int. Ed. 2021, 60, 8932 DOI: 10.1002/anie.202017117
Total synthesis of mannopeptimycin via chemical ligation cyclization
J. Wang, D. Lin, M. Liu, H. Liu, Li, X.*
J. Am. Chem. Soc. 2021. 143, 12784 DOI: 10.1021/jacs.1c05922
Chemical Synthesis and Biological Evaluation of Adiponectin Collagenous Domain Glycoforms
H. Wu, Y. Zhang, Y. Li, J. Xu, Y. Wang*, X. Li*
J. Am. Chem. Soc. 2021, 143, 7808 DOI: 10.1021/jacs.1c02382
Revealing generation, migration and dissociation of electron−hole pairs and current emergence in an organic photovoltaic cell
Z. Xu, Y. Zhou, C.Y. Yam, T. Frauenheim, C. Lienau, G.H. Chen*
Sci. Adv. 2021, 7, eabf7672 DOI: 10.1126/sciadv.abf7672
Rapid Broad Spectrum Detection of Carbapenemases with a Dual Fluorogenic-Colorimetric Probe
C.W. Ma, K.K.H. Ng, B.H.C. Yam, P.L. Ho, R.Y.T. Kao, D. Yang*
J. Am. Chem. Soc. 2021, 18, 6886 DOI: 10.1021/jacs.1c00462
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
H.B. Wang, M.J. Wang, X.H. Xu, P. Gao, Z.L. Xu, Q. Zhang, H.Y. Li, A.X. Yan, R.Y.T. Kao, H.Z. Sun*
Nat. Commun. 2021, 12, 3331 DOI: 10.1038/s41467-021-23659-y
Photoinduced Hydroarylation and Cyclization of Alkenes with Luminescent Platinum(II) Complexes
H. Cheng, T.L. Lam, Y. Liu, Z. Tang, C.M. Che*
Angew.Chem. Int. Ed. 2021, 60, 1383-1389 DOI: 10.1002/anie.202011841
C−H Activation by an Iron-Nitrido Bis-Pocket Porphyrin Species
H.X. Wang, L. Wu, B. Zheng, L. Du, W.P. To, C.H. Ko, D. L. Phillips*, C.M. Che*
Angew.Chem. Int. Ed. 2021, 60,4796 DOI: 10.1002/anie.202014191
Aggregation and Supramolecular Self-Assembly of Low-Energy Red Luminescent Alkynylplatinum(II) Complexes for RNA Detection, Nucleolus Imaging, and RNA Synthesis Inhibitor Screening
A.S.Y. Law, L.C.C. Lee, K.K.W. Lo*, V.W.W. Yam*
J. Am. Chem. Soc. 2021, 143, 5396 DOI: 10.1021/jacs.0c13327
Dual Emissive Gold(I)–Sulfido Cluster Framework Capable of Benzene–Cyclohexane Separation in the Solid State Accompanied by Luminescence Color Changes
L.Y. Yao, V.W.W. Yam*
J. Am. Chem. Soc. 2021, 143, 2558 DOI: 10.1021/jacs.0c11891
Platinum(II)-Based Host–Guest Coordination-Driven Supramolecular Co-Assembly Assisted by Pt···Pt and π–π Stacking Interactions: A Dual-Selective Luminescence Sensor for Cations and Anions
Y.S. Wong, M. Ng, M.C.L. Yeung, V.W.W. Yam*
J. Am. Chem. Soc. 2021, 143, 973 DOI: 10.1021/jacs.0c11162
A tri-functional amino acid enables mapping of binding sites for posttranslational-modification-mediated protein-protein interactions
J. Lin, X. Bao*, X.D. Li*
Mol. Cell 2021, 81, 2669 DOI: 10.1016/j.molcel.2021.04.001
Strong metal–metal Pauli repulsion leads to repulsive metallophilicity in closed-shell d8 and d10 organometallic complexes
Q. Wan*, J. Yang*, W.P. To, C.M Che*
Proc. Natl. Acad. Sci. U.S.A. 2021, 118, e2019265118 DOI: 10.1073/pnas.2019265118
Geometrical manipulation of complex supramolecular tessellations by hierarchical assembly of amphiphilic platinum(II) complexes
J.K.L. Poon, Z. Chen, S.Y.L. Leung, M.Y. Leung, V.W.W. Yam*
Proc. Natl. Acad. Sci. U.S.A. 2021, 118, e2022829118
Catalytic reductive desymmetrization of malonic esters
P. Xu, Z. Huang*
Nat. Chem. 2021, 13, 634 DOI: 10.1038/s41557-021-00715-0
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells
Y. Huang, L. Meng, Q. Nie, Y. Zhou, L. Chen, S. Yang, Y. M. E. Fung, X. Li, C. Huang, Y. Cao,* Y. Li,* X. Li*
Nat. Chem. 2021, 13, 77 DOI: 10.1038/s41557-020-00605-x
Department News
-
04 May 2022
含腐蝕性化學物遇水升溫達90度 專家測試揭自熱食安隱憂
-
30 Mar 2022
Sharing from a Year 4 Chemistry Student (Jasmine Cheung) in Applying for PhD Programmes
-
19 Jan 2022
HKU scientists reveal orally administrated bismuth drug together with N-acetyl cysteine as a potential broad-spectrum anti-coronavirus cocktail therapy
-
19 Jan 2022
港大發現一「雞尾酒療法」可作潛在廣譜口服抗新冠特效藥
-
10 Jan 2022
港大研發新一代抗癌化合物 晚期癌症或有望變成慢性病
-
15 Dec 2021
Dr. Jian HE receives Croucher Innovation Awards 2021 in Croucher Foundation's ceremony
Seminars
-
Croucher Advanced Study Institute 2022 – Metals in Biology and Medicine: From Molecular Imaging to Drug Resistance (PART III)21Jun2022Renowned scholarsRenowned local and overseas institutionsTime: 08:45 - 18:15 via Zoom
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Novel approaches to RNA imaging in live cells05May2022Prof. Dr. Andres JäschkeHeidelberg UniversityTime: 16:30 via Zoom
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Mining the World's Chemical Diversity for New Antibiotics: The Community for Open Antimicrobial Drug Discovery27Apr2022Prof. Mark BlaskovichThe University of QueenslandTime 15:00-16 via Zoom