Our Publications

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  1. Characterization of Glycylglycyltyrosine Radical Cations: Insights into β-Radical Formation and N–Cα Peptide Bond Dissociation at the Tyrosine Residue
    Li, Y, Martens, J Lau,Berden, Oomens, J, Tang WT, Chu IK*, Int. J. Mass Spectrom.. 2024, 506, 117351. [PDF]
  2. Structure and fragmentation chemistry of the peptide radical cations of glycylphenylalanylglycine (GFG)
    Li, Y, Lau, JKC, van Wieringen, T, Martens, J, Berden, G, Oomens, J, Hopkinson AC, Siu KWM, Chu IK*, PLoS ONE. 2024, 19 (8), e0308164. [PDF]
  3. Study of Potential Synergistic Effect of Probiotic Formulas on Acrylamide Reduction
    Siu MC*, Lin H, Xie W, Chu IK, Int. J. Mol. Sci.. 2023, 24 (5), 4693. [PDF]
  4. Study of the Efficacy of Probiotic Bacteria to Reduce Acrylamide in Food and In Vitro Digestion
    Choi SM, Yang L, Chang Y, Chu IK*, Dong N, Foods. 2022, 11(9), 1263.
  5. Mechanistic Examination of Cα–Cβ Tyrosyl Bond Cleavage: Spectroscopic Investigation of the Generation of α-Glycyl Radical Cations from Tyrosyl(glycyl/alanyl)tryptophan
    Li Y, Li M, Spencer DM, Martens J, Berden G, Oomens J, Siu CK, Chu IK*, J Mass Spectrom. 2021, e4630., undefined. [PDF]
  6. Implementation of a multiple-fraction concatenation strategy in an online two-dimensional high-/low-pH reversed-phase/reversed-phase liquid chromatography platform for qualitative and quantitative shotgun proteomic analyses
    Law H, Kong R, Li M, Szeto S, Chu IK*, J Mass Spectrom. 2021, Early View.
  7. Formation of n→π+ Interaction Facilitating Dissociative Electron Transfer in Isolated Tyrosine-containing Molecular Peptide Radical Cations
    Tang WK, Mu X, Li M, Martens J, Berden G, Oomens J, Chu IK*, Siu CK, Phys Chem Chem Phys. 2020, undefined.
  8. rPTMDetermine: A Fully Automated Methodology for Endogenous Tyrosine Nitration Validation, Site-Localization, and Beyond
    Dong N, Spencer DM, Quan Q, Le Blanc JCY, Feng J, Li M, Siu KWM, Chu IK*, Anal Chem. 2020, 92, 10768–10776.
  9. Dissociative electron transfer of copper(II) complexes of glycyl(glycyl/alanyl)tryptophan in vacuo:IRMPD action spectroscopy provides evidence of transition from zwitterionic to non-zwitterionic peptide structures
    Li Y, Li M, Spencer DM, Lau JKC, Martens J, Berden G, Oomens J, Fang DC, Hopkinson AC, Siu KWM, Siu CK, Chu IK*, Phys Chem Chem Phys. 2020, 19, 17637-17652. [PDF]
  10. Evidence for the Prerequisite Formation of Phenoxyl Radical in Radical-Mediated Peptide Tyrosine Nitration In Vacuo
    Lai CK, Tang WK, Siu CK, Chu IK*, Chem Eur J. 2019, 26, 331-335. [PDF]
  11. Structures of [GPGG+H–H2O]+ and [GPGG+H–H2O–NHCH2]+ ions; evidence of rearrangement prior to dissociation
    Lau JKC, Lai CK, Lam KHB, Chu IK, Martens J, Berden G, Oomens J, Hopkinson AC, Siu KWM*, Int J Mass Spectrom. 2019, 442, 51-57. [PDF]
  12. Ca–Cß bond cleavage occurs at the side chain of the N-terminal phenylalanine residue during CID of tyrosine-containing peptide radical cations
    Mu XY, Tang WK, Dong NP, Li MZ, Siu CK*, Chu IK*, Int J Mass Spectrom. 2019, 435, 333-341. [PDF]
  13. Tautomerization and Dissociation of Molecular Peptide Radical Cations
    Mu X, Song T, Siu CK*, Chu IK*, Chem Rec. 2018, 18, 20-44. [PDF]
  14. Loss of water from protonated polyglycines: interconversion and dissociation of the product imidazolone ions
    Lam KHB, Lau JKC, Lai CK, Chu IK, Martens J, Berden G, Oomens J, Hopkinson AC, Siu KWM, Phys Chem Chem Phys. 2018, 20, 18688-18698. [PDF]
  15. Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia
    Law HCH, Szeto SSW, Quan Q, Zhao Y, Zhang Z, Krakovska O, Lui LT, Zheng C, Lee SMY, Siu KWM, Wang Y, Chu IK, J Proteome Res. 2017, 16, 1150-1166. [PDF]
  16. A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity related to antibiotic-associated hemorrhagic colitis
    Tse H, Yang D, Sze KH, Chu IK, Kao RYT, Lee KC, Lam CW, Gu Q, Tai S, Ke Y, Chan E, Chan W M, Dai J, Leung SP, Leung SY, Yuen KY*, J Biol Chem. 2017, 292, 19503-19520. [PDF]
  17. Integrative Approach for the Analysis of the Proteome-wide Response to Bismuth Drugs in Helicobacter pylori
    Wang Y, Hu L, Xu F, Quan Q, Lai YT, Xia W, Yang Y, Chang YY, Yang X, Chai Z, Wang J, Chu IK, Li H, Sun H*, Chem Sci. 2017, 8, 4626-4633. [PDF]
  18. Isomerization versus dissociation of phenylalanylglycyltryptophan radical cations
    Mu X, Lau JKC, Lai CK, Siu KWM, Hopkinson AC*, Chu IK*, Phys Chem Chem Phys. 2017, 19, 16923-33. [PDF]
  19. Phosphoproteome of Crab-Eating Macaque Cerebral Cortex Characterized Through Multidimensional Reversed-Phase Liquid Chromatography/Mass Spectrometry With Tandem Anion/Cation Exchange Columns
    Quan Q, Feng JW, Lui LT, Shi TL, Chu IK*, J Chromatogr A. 2017, 1498, 196-206. [PDF]
  20. Ground and Excited-Electronic-State Dissociations of Hydrogen-Rich and Hydrogen-Deficient Tyrosine Peptide Cation Radicals
    Turecek F*, Viglino E, Lai CK, Mu X, Chu IK*, J Am Soc Mass Spectrom. 2016, 27(9), 1454-1467. [PDF]
  21. Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy
    Zhang ZJ, Zhang GX, Sun Y, Szeto SSW, Law CH, Quan Q, Li GH, Yu P, Sho E, Siu MKW, Lee SMY, Chu IK*, Wang Y, Sci Rep. 2016, 6, 37148. [PDF]
  22. Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson’s Disease Through LC/MS-Based Multivariate Data Analysis-Guided Fractionation
    Li GH, Zhang ZJ, Quan Q, Jiang R, Szeto SS, Yuan S, Wong WT, Lam HH, Lee SMY*, Chu IK*, J Proteome Res. 2016, 15(8), 2595-606. [PDF]
  23. Nucleophilic substitution by amide nitrogen in the aromatic rings of [zn-H]•+ ions; the structures of the [b2-H-17]•+ and [c1-17]+ ion
    Mu X, Lau JKC, Lai KC, Siu KWM, Hopkinson AC*, Chu IK*, Phys Chem Chem Phys. 2016, 18, 11168-11175. [PDF]
  24. Label-free quantitative proteomics reveals survival mechanisms developed by hypertrophic chondrocytes under ER stress
    Kudelko M, Chan C, Sharma R, Yao Q, Lau E, Chu IK, Cheah K, Tanner J, Chan D, J Proteome Res. 2016, 15, 86-99. [PDF]
  25. Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis
    Yee A, Lam M, Chu IK, Cheah KS, Cheung KM, Chan D, Osteoarthritis Cartilage. 2016, 24, 503-513. [PDF]
  26. Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography
    Wang YC, Kong RPW, Chu IK, Wang JW, Li HY, Sun HZ, Chem Comm. 2015, 51, 16479-16482. [PDF]
  27. Comparative and quantitative proteomics reveal the adaptive strategies of oyster larvae to ocean acidification
    Dineshram R, Quan Q, Sharma R, Chandramouli K, Yalamanchili HK, Chu IK, Thiyagarajan V*, Proteomics. 2015, 15, 4120-4134. [PDF]
  28. α-Radical-induced CO2 loss from the aspartic acid side chain of the collisionally induced tripeptide aspartylglycylarginine radical cation
    Xu M, Tang WK, Mu X, Ling Y, Siu CK*, Chu IK*, Int J Mass Spectrom. 2015, 390, 56-62. [PDF]
  29. Proposed nomenclature for peptide ion fragmentation
    Chu IK, Siu CK, Lau JKC, Tang WK, Mu X, Lai CK, Guo X, Wang X, Li N, Xia Y, Kong X, Oh HB, Ryzhov V, Turecek F, Hopkinson AC, Siu KWM, Int J Mass Spectrom. 2015, 390, 24-27. [PDF]
  30. Fully automated multidimensional reversed-phase liquid chromatography with tandem anion/cation exchange columns for simultaneous global endogenous tyrosine nitration detection, integral membrane protein characterization, and quantitative proteomics mapping in cerebral infarcts
    Quan Q, Szeto SSW, Law CH, Zhang Z, Wang Y, Chu IK, Anal Chem. 2015, 87, 10015-10024. [PDF]
  31. Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents
    Cui G, Shan L, Chu IK, Li G, Leung GPH, Wang Y, Kwan YW, Hoi MPM, Lee SMY, RSC Adv. 2015, 5, 74605-74610. [PDF]
  32. Online Coupling of Hydrophilic Interaction/Strong Cation Exchange/Reversed-Phase Liquid Chromatography with Porous Graphitic Carbon Liquid Chromatography for Simultaneous Proteomics and N-Glycomics Analysis
    Zhao Y, Law CH, Zhang Z, Lam C, Quan Q, Li G, Chu IK, J Chromatogr A. 2015, 1415, 57-66. [PDF]
  33. Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy
    Cui G, Shan L, Guo L, Chu IK, Li G, Quan Q, Zhao Y, Chong C, Zhang Z, Yu P, Hoi MPM, Sun Y, Wang Y, Lee SMY, Sci Rep. 2015, 5, 13509. [PDF]
  34. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson's disease
    Zhang Z, Li G, Szeto SSW, Chong C, Quan Q, Huang C, Cui W, Guo B, Wang Y, Han Y, Siu MKW, Lee SMY, Chu IK, Free Radic Biol Med. 2015, 84, 331-343. [PDF]
  35. A Versatile Reversed Phase-Strong Cation Exchange-Reversed Phase (RP-SCX-RP) Multidimensional Liquid Chromatography Platform for Qualitative and Quantitative Shotgun Proteomics
    Law CH, Kong PW, Szeto SSW, Li G, Quan Q, Zhang Z, Chu IK, Analyst. 2015, 140, 1237-1252. [PDF]
  36. Fully automatable multidimensional reversed-phase liquid chromatography with online tandem mass spectrometry
    Lam MPY, Law CH, Quan Q, Zhao Y, Chu IK, Shotgun Proteomics: Methods and Protocols, Methods in Molecular Biology. 2014, 1156, 39-51. [PDF] [Supplementary]
  37. Online Two-Dimensional Porous Graphitic Carbon/Reversed Phase Liquid Chromatography Platform Applied to Shotgun Proteomics and Glycoproteomics
    Zhao Y, Szeto SSW, Kong PW, Law CH, Li G, Quan Q, Zhang Z, Chu IK, Anal Chem. 2014, 86, 12172-12179. [PDF]
  38. Formation, isomerization, and dissociation of ε- and α-carbon-centered tyrosylglycylglycine radical cations
    Lai CK, Mu X, Hao Q, Hopkinson AC, Chu IK, Phys Chem Chem Phys. 2014, 16, 24235-24243. [PDF]
  39. Discovery and Mechanistic Studies of Facile N-Terminal Cα-C Bond Cleavages in the Dissociation of Tyrosine-Containing Peptide Radical Cations
    Mu X, Song T, Xu M, Lai CK, Siu CK, Laskin J, Chu IK, J Phys Chem B. 2014, 118, 4273-4281. [PDF]
  40. Mechanistic Examination of Cβ-Cγ Bond Cleavages of Tryptophan Residues During Dissociations of Molecular Peptide Radical Cations
    Song T, Ma CY, Chu IK, Siu CK, Laskin J*, J Phys Chem A. 2013, 117, 1059-1068. [PDF]
  41. Mechanistic investigation of phosphate-ester bond cleavages of glycylphosphoserinyltryptophan radical cations under low-energy collision-induced dissociations
    Quan Q, Song T, Hao Q, Siu CK, Chu IK, J Am Soc Mass Spectrom. 2013, 24, 554-562. [PDF]
  42. The identification of CD147 (Basigin) as a mediator of trophoblast functions
    Lee CL, Lam MPY, Lam K, Leung CON, Pang R, Chu IK, Wan THL, Chai J, Yeung W, Chiu P, Human Reprod. 2013, 28, 2920-2929. [PDF]
  43. Goldfish spexin: solution structure and novel function as a satiety factor in feeding control
    Wong MKH*, Sze KH, Chen T, Cho CK, Law HCH, Chu IK, Wong AOL, Am J Physiol Endocrinol Metab. 2013, 305(3), E348-E366. [PDF]
  44. Laser-Induced Dissociation of Singly Protonated Peptides at 193 and 266 nm within a Hybrid Linear Ion Trap Mass Spectrometer
    Lai CK, Ng DCM, Pang HF, Cheung ASC, Chu IK, Rapid Commun Mass Spectrom. 2013, 1119-1127, undefined. [PDF]
  45. Proteomic evidence for genetic epistasis: ClpR4 mutations switch leaf variegation to virescence in Arabidopsis
    Wu W, Zhu Y, Ma Z, Sun Y, Quan Q, Li P, Hu P, Shi T, Lo C, Chu IK, Huang J*, Plant J. 2013, 76, 943-956. [PDF]
  46. Adrenomedullin Enhances Invasion of Human Extravillous Cytotrophoblast-Derived Cell Lines by Regulation of Urokinase Plasminogen Activator Expression and S-Nitrosylation
    Wong BST, Lam KKW, Lee CL, Wong VHH, Lam MPY, Chu IK, Yeung WSB, Chiu PCN*, Biol Reprod. 2013, 88, 34. [PDF]
  47. Formation and Dissociation of Phosphorylated Peptide Radical Cations
    Kong RPW, Quan Q, Hao Q, Lai CK, Siu CK, Chu IK, J Am Soc Mass Spectrom. 2012, 23, 2094-2101. [PDF]
  48. Effect of the basic residue on the energetics and dynamics of dissociation of phosphopeptides
    Laskin J, Kong RPW, Song T, Chu IK, Int J Mass Spectrom. 2012, 330-332, 295-301. [PDF]
  49. Arginine-Facilitated Isomerization: Radical-Induced Dissociation of Aliphatic Radical Cationic Glycylarginyl(Iso)leucine Tripeptides
    Hao Q, Song T, Ng DCM, Quan Q, Siu CK*, Chu IK*, J Phys Chem B. 2012, 116, 7627-7634. [PDF]
  50. Intramolecular hydrogen atom migration along the backbone of cationic and neutral radical tripeptides andsubsequent radical-induced dissociations
    Zhao JF, Siu KWM, Hopkinson AC, Song T, Xu MJ, Quan Q, Chu IK, Phys Chem Chem Phys. 2012, 14, 8723-8731. [PDF]
  51. Fully automatable two-dimensional HILIC-RP liquid chromatography with online tandem mass spectrometry for shotgun proteomics
    Zhao Y, Kong RPW, Li GH, Lam MPY, Law CH, Lee S, Lam HC, Chu IK*, J Sep Sci. 2012, 35, 1755-1763. [PDF]
  52. Energy and entropy effects in dissociation of peptide radical anions
    Laskin J*, Yang ZB, Lam C, Chu IK, Int J Mass Spectrom. 2012, 316-318, 251-258. [PDF]
  53. Novel Cβ-Cγ Bond Cleavages of Tryptophan-Containing Peptide Radical Cations
    Song T, Hao Q, Law CH, Siu CK, Chu IK, J Am Soc Mass Spectrom. 2012, 23, 264-273. [PDF]
  54. Ethanolic Extract of Fructus Alpinia oxyphylla Protects Against 6-Hydroxydopamine-Induced Damage of PC12 Cells In Vitro and Dopaminergic Neurons in Zebrafish
    Zhang ZJ, Cheang LC, Wang MW, Li GH, Chu IK, Lin ZX, Lee SM*, Cell Mol Neurobiol. 2012, 32, 27-40. [PDF]
  55. Metabolism of calycosin, an isofavone from Astragali Radix, in zebrafish larvae
    Hu G, Shiu SO, Li S, Chu IK, Kwan YW, Chan SW, Leung GPH, Yan R, Lee SMY*, Xenobiotica. 2012, 42(3), 294-303. [PDF]
  56. Formation of peptide radical ions through dissociative electron transfer in ternary metal-ligand-peptide complexes
    Chu IK, Laskin J, Eur J Mass Spectrom (Chichester). 2011, 17, 543-556. [PDF]
  57. Online Combination of Reverse-Phase/Reverse-Phase and Porous Graphitic Carbon Liquid Chromatography for Multicomponent Separation of Proteomics and Glycoproteomics Samples
    Lam MPY, Lau E, Siu SO, Ng DCM, Chiu PCN, Yeung WSB, Lo C, Chu IK, Electrophoresis. 2011, 32, 2930-2940. [PDF]
  58. Combined in vivo Imaging and Omic Approaches Reveal Metabolism of Icaritin and its Glycosides in Zebrafish Larvae
    Li ZH, Alex D, Siu SO, Chu IK, Renn J, Winkler C, Lou S, Tsui SKW, Zhao HY, Yan WR, Mahady GS, Li GH, Kwan YW, Wang YT, Lee SMY, Mol Biosyst. 2011, 7, 2128-2138. [PDF]
  59. Development of online high-/low-PH reverse-phase/reverse-phase two-dimensional liquid chromatography for shotgun proteomics: An RP-SCX-RP approach
    Kong RPW, Siu SO, Lee SMY, Lo C, Chu IK*, J Chromatogr A. 2011, 1218, 3681-3688. [PDF]
  60. Combinatorial use of offline SCX and online RP-RP Liquid Chromatography for iTRAQ-based quantitative Proteomics Applications
    Lau E, Lam MPY, Siu SO, Lo C, Chu IK*, Mol Biosyst. 2011, 7, 1399-1408. [PDF]
  61. Fully Automatable Two-Dimensional Reversed-Phase Capillary Liquid Chromatography with Online Tandem Mass Spectrometry for Shotgun Proteomics
    Siu SO, Lam MPY, Lau E, Kong PW, Zhang J, Lee SMY, Chu IK, Proteomics. 2011, 11, 2308-2319. [PDF]
  62. Effect of the N-Terminal Basic Residue on Facile Cα-C Bond Cleavages of Aromatic-Containing Peptide Radical Cations
    Xu MJ, Song T, Quan Q, Fang DC, Siu CK, Chu IK, Phys Chem Chem Phys. 2011, 13(13), 5888-5896. [PDF]
  63. Arginine-Facilitated α- and π-Radical Migrations in 6 Glycylarginyltryptophan Radical Cations
    Song T, Ng DCM , Quan Q, Siu CK, Chu IK, Chem Asian J. 2011, 6, 888-898. [PDF]
  64. Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy
    Lee CL, Chiu PCN, Lam KKW, Siu SO, Chu IK, Koistinen R, Koistinen H, SeppäläM, Lee KF, Yeung WSB, Human reprod. 2011, 26, 517-526. [PDF]
  65. N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry
    Siu SO, Lam MP, Lau E, Yeung WS, Cox DM, Chu IK, Functional Glycomics: Methods and Protocols. 2010, 600, 133-143. [PDF]
  66. Nuclear-based Metallomics in Metal-based Drugs
    Ge RG, Chu IK, Sun HZ, Advanced Nuclear Analytical Techniques for Metallomics and Metalloproteomics. 2010, 265-298. [PDF]
  67. CYP93G2 is a flavanone a-hydroxylase required for C-glycosyl-flavone biosynthesis in rice
    Du YG, Chu H, Chu IK, Lo C*, Plant Physiol. 2010, 154, 324-333. [PDF]
  68. The Effect of the Basic Residue on the Energetics, Dynamics, and Mechanisms of Gas-Phase Fragmentation of Protonated Peptides
    Laskin J, Yang ZB, Song T, Lam CNW, Chu IK, J Am Chem Soc. 2010, 132(45), 16006-16016. [PDF]
  69. Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization
    Lam MPY, Siu SO, Lau E, Mao X, Sun, HZ, Chiu, PCN, Yeung WSB, Cox DM, Chu IK, Anal Bioanal Chem. 2010, 398, 791-804. [PDF]
  70. Glycodelin-A modulates cytokine production of peripheral blood natural killer cells
    Lee CL, Chiu PC*, Lam KK, Chan RW, Chu IK, Koistinen R, Koistinen H, Seppala M, Lee KF, Yeung WS, Fertil Steril. 2010, 94, 769-771. [PDF]
  71. Fragmentation of α-Radical Cations of Arginine-Containing Peptides
    Laskin J, Yang ZB, Ng DCM, Chu IK, J Am Soc Mass Spectrom. 2010, 21, 511-521. [PDF]
  72. Formation, Isomerization, and Dissociation of α-Carbon-Centered and π-Centered Glycylglycyltryptophan Radical Cations
    Ng CM, Song T, Siu SO, Siu CK, Laskin J, Chu IK, J Phys Chem B. 2010, 114, 2270-2280. [PDF]
  73. OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast functions
    Liu HJ, Chu H, Lau E, Lam MPY, Li SJ, Huang G, Guo P, Jiang LW, Chu IK, Lo C, Tao YZ, New Phytologist. 2010, 187, 83-105. [PDF]
  74. Identification of flavone phytoalexins and a pathogen-inducible flavone synthase Ⅱ gene ( SbFNSⅡ,) in sorghum
    Du YG, Chu H, Wang MF, Chu IK, Lo C, J Exp Bot. 2010, 61, 983-994. [PDF]
  75. Molecular dissection of the pathogen-inducible 3-deoxyanthocyanidin biosynthesis pathway in sorghum
    Liu H, Du Y, Chu H, Shih CH, Wong YW, Wang M, Chu IK, Tao Y, Lo C, Plant Cell Physiol. 2010, 51, 1173-1185. [PDF]
  76. Direct Trapping of Acrylamide as a Key Mechanism for Niacin's Inhibitory Activity in Carcinogenic Acrylamide Formation
    Zeng XH, Kong RPW, Cheng KW, Du YG, Tang YS, Chu IK, Lo C, Sze KH, Chen F, Wang MF, Chem Res Toxicol. 2010, 23, 802-807. [PDF]
  77. Activities of hydrocolloids as inhibitors of acrylamide formation in model systems and fried potato strips
    Zeng XH, Cheng KW, Du YG, Kong R, Lo C, Chu IK, Chen F, Wang MF, Food Chemistry. 2010, 121, 424-428. [PDF]
  78. Effects of melamine on the Maillard reaction between lactose and phenylalanine
    Ma JY, Peng XF, Cheng KW, Kong R, Chu IK, Chen F, Wang MF, Food Chemistry. 2010, 1-6, undefined. [PDF]
  79. Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1
    Qi H, Siu SO, Chen Y, Han Y, Chu IK, Tong Y, Lau AS, Rong J, Chem Biol Interact. 2010, 183, 380-389. [PDF]
  80. Experimental and Computational Studies of the Macrocyclic Effect of an Auxiliary Ligand on Electron and Proton Transfers Within Ternary Copper(II)-Histidine Complexes
    Song T, Lam CNW, Ng DCM, Orlova G, Laskin J, Fang DC, Chu IK, J Am Soc Mass Spectrom. 2009, 20, 972-984. [PDF]
  81. Methionine, alpha-methylmethionine and S-methylcysteine radical cations: generations and dissociations in the gas phase
    Zhao J, Ng CM, Chu IK, Siu KW, Hopkinson AC, Phys Chem Chem Phys. 2009, 11(35), 7629-7639. [PDF]
  82. Kinetics for Tautomerizations and Dissociations of Triglycine Radical Cations
    Siu CK, Zhao JF, Laskin J, Chu IK, Hopkinson AC, Siu KWM, J Am Soc Mass Spectrom. 2009, 996-1005, undefined. [PDF]
  83. Effects of Differential Glycosylation of Glycodelins on Lymphocyte Survival
    Lee CL, Pang PC, Yeung WSB, Tissot B, Panico M, Lao TTH, Chu IK, Lee KF, Chung MK, Lam KKW, Koistinen R, Koistinen H, Seppälä M, Morris HR, Dell A, Chiu PC*, J Bio Chem. 2009, 284, 15084-15096. [PDF]
  84. Inhibitory mechanism of naringenin against carcinogenic acrylamide formation and nonenzymatic browning in Maillard model reactions
    Cheng KW, Zeng X, Tang YS, Wu JJ, Liu Z, Sze KH, Chu IK, Chen F, Wang M, Chem Res Toxicol. 2009, 22(8), 1483-1489. [PDF]
  85. Inhibition of mutagenic PhIP formation by epigallocatechin gallate via scavenging of phenylacetaldehyde
    Cheng KW, Wong CC, Chao J, Lo C, Chen F, Chu IK, Che CM, Ho CT, Wang M*, Mol Nutr Food Res. 2009, 53(6), 716-725. [PDF]
  86. Applications of Proteomics in Food Research
    Chu IK, Lau E, Ma CY, International Review Food Science and Technology. 2008, 1, 32-37.
  87. Accumulation of trans,-piceid in sorghum seedlings infected with Colletotrichum sublineolu
    Yu CK, Shih CH, Chu IK, Lo C, Phytochemistry. 2008, 69(3), 700-706. [PDF]
  88. The Effect of the Secondary Structure on Dissociation of Peptide Radical Cations: Fragmentation of Angiotensin III and Its Analogues
    Yang Z, Lam C, Chu IK, Laskin J, J Phys Chem B. 2008, 112(39), 12468-12478. [PDF]
  89. Functional characterization of key structural genes in rice flavonoid biosynthesis
    Shih CH, Chu H, Tang LK, Sakamoto W, Maekawa M, Chu IK, Wang M, Lo C, Planta. 2008, 228(6), 1043-1054. [PDF]
  90. Accumulation of isoflavone genistin in transgenic tomato plants overexpressing a soybean isoflavone synthase gene
    Shih CH, Chen YL, Wang MF, Chu IK, Lo C*, J Agr Food Chem. 2008, 56(14), 5655-5661. [PDF]
  91. Microwave-assisted nonspecific proteolytic digestion and controlled methylation for glycomics applications
    Liu X, Chan K, Chu IK, Li J, Carbohydr Res. 2008, 343, 2870-2877. [PDF]
  92. Energetics and dynamics of electron transfer and proton transfer in dissociation of metalIII(salen)-peptide complexes in the gas phase
    Laskin J, Yang Z, Chu IK, J Am Chem Soc. 2008, 130(10), 3218-3230. [PDF]
  93. Are the radical centers in peptide radical cations mobile? The generation, tautomerism, and dissociation of isomeric α-carbon-centered triglycine radical cations in the gas phase
    Chu IK, Zhao J, Xu MJ, Siu SO, Hopkinson AC, Siu KWM, J Am Chem Soc. 2008, 130(25), 7862-7872. [PDF]
  94. Trapping of phenylacetaldehyde as a key mechanism responsible for naringenin's inhibitory activity in mutagenic 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine formation
    Cheng KW, Wong CC, Cho CK, Chu IK, Sze KH, Lo C, Chen F, Wang M, Chem Res Toxicol. 2008, 21(10), 2026-2034. [PDF]
  95. Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings
    Shih CH, Siu SO, Ng R, Wong E, Chiu LCM, Chu IK, Lo C, J Agric Food Chem. 2007, 55(2), 254-259. [PDF]
  96. Detection, characterization, and quantification of resveratrol glycosides in transgenic arabidopsis over-expressing a sorghum stilbene synthase gene by liquid chromatography/tandem mass spectrometry
    Lo C, Le Blanc JC, Yu CK, Sze KH, Ng DC, Chu IK, Rapid Commun Mass Spectrom. 2007, 21(24), 4101-4108. [PDF]
  97. Charge-remote fragmentation of odd-electron peptide ions
    Laskin J, Yang ZB, Lam C, Chu IK, Anal Chem. 2007, 79(17), 6607-6614. [PDF]
  98. Is dissociation of peptide radical cations an ergodic process?
    Laskin J, Futrell JH, Chu IK, J Am Chem Soc. 2007, 129(31), 9598-9599. [PDF]
  99. Constitutive accumulation of cis-piceid in transgenic Arabidopsis overexpressing a sorghum stilbene synthase gene
    Yu CKY, Lam CNW, Springob K, Schmidt J, Chu IK, Lo C, Plant Cell Physiology. 2006, 47(7), 1017-1021. [PDF]
  100. Differential expression of two flavonoid 3'-hydroxylase cDNAs involved in biosynthesis of anthocyanin pigments and 3-deoxyanthocyanidin phytoalexins in sorghum
    Shih CH, Chu IK, Yip WK, Lo C, Plant Cell Physiol. 2006, 47(10), 1412-1419. [PDF]
  101. A sheath-flow nanoelectrospray interface of microchip electrophoresis MS for glycoprotein and glycopeptide analysis
    Mao X, Chu IK*, Lin B*, Electrophoresis. 2006, 27(24), 5059-5067. [PDF]
  102. Macrocyclic effect of auxiliary ligand on the gas-phase dissociation of ternary copper(II)-GGX complexes
    Lam CNW, Siu SO, Orlova G, Chu IK, Rapid Commun Mass Spectrom. 2006, 20(5), 790-796. [PDF]
  103. Non-zwitterionic structures of aliphatic-only peptides mediated the formation and dissociation of gas phase radical cations
    Lam CNW, Ruan EDL, Ma CY, Chu IK*, J Mass Spectrom. 2006, 41(7), 931-938. [PDF]
  104. Formation of anionic peptide radicals in vacuo
    Lam CNW, Chu IK, J Am Soc Mass Spectrom. 2006, 17(9), 1249-1257. [PDF]
  105. A stilbene synthase gene (SbSTS1) is involved in host and nonhost defense responses in Sorghum
    Yu CKY, Springob K, Schmidt JR, Nicholson RL, Chu IK, Yip WK, Lo C, Plant Physiol. 2005, 138(1), 393-401. [PDF]
  106. Facile generation of tripeptide radical cations in vacuo via intramolecular electron transfer in CuII tripeptide complexes containing sterically encumbered terpyridine Ligands
    Chu IK*, Lam CNW, Siu SO, J Am Soc Mass Spectrom. 2005, 16(5), 763-771. [PDF]
  107. Generation of peptide radical dications via low-energy collision-induced dissociation of [CuII(terpy)(M+H)]•3+
    Chu IK*, Lam CNW, J Am Soc Mass Spectrom. 2005, 16(11), 1795-1804. [PDF]
  108. Formation of molecular radical cations of aliphatic tripeptides from their complexes with CuII(12-crown-4)
    Chu IK*, Siu SO, Lam CNW, Chan JCY, Rodriquez CF, Rapid Commun Mass Spectrom. 2004, 18(16), 1798-1802. [PDF]
  109. Copper-mediated peptide radical ions in the gas phase
    Bagheri-Majdi E, Ke YY, Orlova G, Chu IK, Hopkinson AC, Siu KWM, J Phys Chem B. 2004, 108(30), 11170-11181. [PDF]
  110. Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity proteomics applications
    Le Blanc JC, Hager JW, Ilisiu AM, Hunter C, Zhong F, Chu IK, Proteomics. 2003, 3(6), 859-869. [PDF]
  111. Sequencing of argentinated peptides by means of matrix-assisted laser desorption/ionization tandem mass spectrometry
    Chu IK, Cox DM, Guo X, Kireeva I, Lau TC, McDermott JC, Siu KW, Anal Chem. 2002, 74(9), 2072-2082. [PDF]
  112. Proton affinities of methyl esters of N-acetylated amino acids
    Addario V, Guo YZ, Chu IK, Ling Y, Ruggerio G, Rodriquez CF, Hopkinson AC, Siu KWM, Int J Mass Spectrom. 2002, 219, 101-114. [PDF]
  113. Proton migration and tautomerism in protonated triglycine
    Rodriquez CF, Cunje A, Shoeib T, Chu IK, Hopkinson AC, Siu KWM, J Am Chem Soc. 2001, 123(13), 3006-3012. [PDF]
  114. Characterization of the product ions from the collision-induced dissociation of argentinated peptides
    Chu IK, Shoeib T, Guo X, Rodriquez CF, Lan TC, Hopkinson AC, Siu KWM, J Am Soc Mass Spectrom. 2001, 12(2), 163-175. [PDF]
  115. Formation of molecular radical cations of enkephalin derivatives via collision-induced dissociation of electrospray-generated copper (II) complex ions of amines and peptides
    Chu IK, Rodriguez CF, Rodriguez F, Hopkinson AC, Siu KWM, J Am Soc Mass Spectrom. 2001, 12(10), 1114-1119. [PDF]
  116. Comparison between protonation, lithiation, and argentination of 5-oxazolones: A study of a key intermediate in gas-phase peptide sequencing
    Rodriquez CF, Shoeib T, Chu IK, Siu KWM, Hopkinson AC, J Phys Chem A. 2000, 104(22), 5335-5342. [PDF]
  117. Solvent-assisted rearrangements between tautomers of protonated peptides
    Rodriquez CF, Cunje A, Shoeib T, Chu IK, Hopkinson AC, Siu KWM, J Phys Chem A. 2000, 104(21), 5023-5028. [PDF]
  118. Elimination of AgR (R = H, CH3, C6H5) from collisionally-activated argentinated amines
    Grewal RN, Rodriquez CF, Shoeib T, Chu IK, Tu YP, Hopkinson AC, Siu KWM, Eur J Mass Spectrom. 2000, 6(2), 187-192. [PDF]
  119. Synthesis, crystal structure and electrospray ionisation mass spectrometry of a novel one-dimensional cyano-bridged Ni(II)-Au(I) polymer
    Chu IK, Shek IPY, Siu KWM, Wong WT, Zuo JL, Lau TC, New J Chem. 2000, 24(10), 765-769. [PDF]
  120. Molecular radical cations of oligopeptides
    Chu IK, Rodriquez CF, Lau TC, Hopkinson AC, Siu KWM, J Phys Chem B. 2000, 104(15), 3393-3397. [PDF]
  121. α, ω-diaminoalkanes as models for bases that dicoordinate the proton: An evaluation of the kinetic method for estimating their proton affinities
    Wang Z, Chu IK, Rodriquez CF, Hopkinson AC, Siu KWM, J Phys Chem A. 1999, 103(43), 8700-8705. [PDF]
  122. A possible origin of [M-nH+mX](m-n)+ ions (X = alkali metal ions) in electrospray mass spectrometry of peptides
    Rodriquez CF, Fournier R, Chu IK, Hopkinson AC, Siu KWM, Int J Mass Spectrom. 1999, 192, 303-317. [PDF]
  123. Sequencing of argentinated peptides by means of electrospray tandem mass spectrometry
    Chu IK, Guo X, Lau TC, Siu KW, Anal Chem. 1999, 71(13), 2364-2372. [PDF]
  124. Intraionic, interligand proton transfer in collision-activated macrocyclic complex ions of nickel and copper
    Chu IK, Lau TC, Siu KWM, J Mass Spectrom. 1998, 33(9), 811-818. [PDF]