Welcome to the
Biological Mass Spectrometry Laboratory.

Biological Mass Spectrometry

Mass spectrometry has become a prominent tool in biological research because of its high sensitivity, accuracy and efficiency. Our cross-disciplinary group is actively engaged in the fundamentals, instrumentation, applied aspects, and data analytics of biological mass spectrometry.

In applications, we are identifying and quantifying proteins in complex biological samples. We aim to discover and quantify proteomes and metabolites in model systems. In addition, our group is working on the development of instrumentation and methodologies that will further the analytical capabilities that power these studies.

To study the fundamental pathways and energetics of peptide radical ion formation and dissociation we combine the power of computational models and experimentation. Through our investigation into the mechanism of generation and dissociation of peptide radical species, we seek to better our understandings of the fundamental chemistries involved in biological mass spectrometry.

Selected Publications

1. Dong N, Spencer DM, Quan Q, Le Blanc JCY, Li MZ, Siu KWM, Chu IK. Anal. Chem., 2020, in press.
2. Lai CK, Tang WK, Siu CK, Chu IK. Chem. Eur. J., 2019, 26, 331. (Hot paper)
3. Law CH, Szeto SSW, Wang Y, Chu IK. J. Proteome Res., 2017, 16, 1150. (Cover Page)
4. Quan Q, Szeto SSW, Law CH, Zhang Z, Wang Y, Chu IK. Anal. Chem., 2015, 87, 10015.
5. Zhang ZJ, Li G, Szeto SSW, Lee SMY, Chu IK. Free Radic. Biol. Med., 2015, 84, 331.
6. Zhao Y, Szeto SSW, Kong PW, Law CH, Li G, Quan Q, Zhang Z, Chu IK. Anal. Chem., 2014, 86 (24), 12172.
7. Laskin J, Yang ZB, Song T, Lam CNW, Chu IK. J. Am, Chem. Soc., 2010, 132 (45), 16006.
8. Laskin J, Yang Z, Chu IK. J. Am. Chem. Soc., 2008, 130, 3218.
9. Chu IK, Zhao J, Xu M, Siu SO, Hopkinson AC, Siu KWM. J. Am. Chem. Soc., 2008, 130, 7862.
10. Laskin J, Futrell JH, Chu IK. J. Am. Chem. Soc., 2007, 129, 9598.

All publications.