143.  Sun, Z.; Liu, H.; Li, X.*
Precision in protein chemical modification and total synthesis
Chem 2023, doi.org/10.1016/j.chempr.2023.10.020

142.  Wu, X.; Sun, Z.; Li, X.*
N,O-Benzylidene Acetal Dipeptides (NBDs) Enable the Synthesis of Difficult Peptides via a Kinked Backbone Strategy.
Angew. Chem. Int. Ed. 2023, e202310624

141.  Ma, W.; Liu, H.*; Li, X.*
Chemical Synthesis of Peptides and Proteins Bearing Base-Labile Post-Translational Modifications: Evolution of the Methods in Four Decades.
ChemBioChem 2023, 24, e202300348

140.  Guo, X.; Li, P.; Liu, H.*; Li, X.*
Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids.
Org. Chem. Front. 2023,10, 3429-3446

139.  Zhang, Y.; Yin, R.; Jiang, H.; Wang, C.; Wang, X.; Wang, D.; Zhang, K.; Yu, R.*; Li, X.*; Jiang, T.*
Peptide stapling through site-directed conjugation of triazine moieties to the tyrosine residues of the peptide.
Org. Lett. 2023, 25, 2248-2252

138.  Chen, Q.; Liu, H.; Li, X.*
The Essential Functions, Syntheses and Detection of Sialyl Lewis X on Glycoproteins.
Exploration of Drug Science 2023, 1: 31–54

137.  Cheung C. H. P.; Chong, T. H.; Wei, T.; Liu, H.*; Li, X.*
Enabling intermolecular OPA-amine-thiol three-component reactions for modular construction.
Angew. Chem. Int. Ed. 2023, 62, e202217150

136.  Sun, Z.; Wei, T.; Cao, Y.; Li, X.*
Protocol for semisynthesis of serotonylated histone H3 by rapid protein desulfurization in tandem with native chemical ligation.
STAR Protocols 2023, 4, 102042

135.  Wu, H.; Tan, Y.; Ngai, W. L.; Li, X.
Total synthesis of interleukine-2 via Tunable Backbone Modification strategy
Chem. Sci. 2023, 14, 1582-1589.

134.  Guo, X.; Shen, B.; Liu, C.; Zhao, H.; Li, X.*; Yu, P.*; Li, P*
Rational design and organocatalytic enantioselective [1+4]-annualations of MBH carbonates with modified enones.
Org. Chem. Front. 2023, 10, 150-156.

133.  Ma, W.; Wu, H.; Liu, S.; Wei, T.; Li, X. D.; Liu, H.*; Li, X.*
Chemical synthesis of proteins with base-labile posttranslational modifications enabled by a Boc-SPPS based general strategy towards peptide C-terminal salicylaldehyde esters.
Angew. Chem. Int. Ed. 2023. (hot paper), 62, e202214053

132.  Gong, H-R.; Hu, Y-F.; Li, X.; Yau, T.; Zhang, B-Z.; Huang, J*
Non-neutralising Epitopes Shade Neutralising Epitopes against Omicron in a Multiple Epitope-based Vaccine
ACS Infect. Dis. 2022, 8, 2586

131.  Ngai, P.; Cheng, Lee, A. H.; Xu, J.; Wei, C. J. W., Liu, J.; Hu, M.; Sun, Z. Neelakatan, P.; Li, X.*; Zhang, C.*
Effects of L-Chg10-teixobactin on viability, proliferation and osteo/odontogenic differentiation of stem cells from apical apilla.
J. Endodonitics 2022, S0099-2399, 22, 00758-0.

130.  Wei, T.#; Li, D.#; Zhang, Y.#; Tang, Y.; Zhou, H.; Liu, H.*; Li, X.*
Thiophene-2,3-dialdehyde enables chemoselective cyclization on unprotected peptides, proteins and phage displayed peptides.
Small Methods 2022, 6, 2201164. (impact factor: 15.367)


129.  Sun, Z.; Ma, W.; Cao, Y.; Wei, T.; Chow, H.Y.; Tan, Y.; Cheung, C.H.P.; Liu, J.; Lee, H.K.; Liu, H.; Li, X.*
Superfast Desulfurization for Protein Chemical Synthesis and Modification.
Chem 2022. 144, 14748-14757

128.  Wu, H.; Wei, Tong.; Ngai, W. L.; Zhou, H. Y.; Li, X.*
Ligation Embedding Aggregation Disruptor Strategy Enables the Chemical Synthesis of PD-1 Immunoglobulin and Extracellular Domains.
J. Am. Chem. Soc. 2022. 144, 14748-14757

127.  Chow, H. Y.; Po, K. H. L.; Chen, S.; Li, X.*
Studies on daptomycin lactam-based analogues.
J. Pept. Sci. 2022. e3430

126.  Liu, J.; Li, X.*
Serine/Threonine ligation and Cysteine/Penicillamine ligation.
Methods Mol. Biol. 2022. 2530, 33-43.
Included in Chemical Protein Synthesis for Methods in Molecular Biology.
Springer Nature 2022. (Editor)

125.  Jarkhi, A.; Lee, A.H.C.; Sun, Z.; Hu, M.; Neelakantan, P.; Li, X.; Zhang, C.*
Antimicrobial effects of L-Chg10-teixobactin against Enterococcus faecalis in vitro.
Microorganisms 2022. 10, 1099.

124.  Jiang, H.; Zhang, Q.; Zhang, Y.; Feng, H.; Pu, F.; Yu, R.; Zhong, Z.; Wang, C.; Fung, Y. M. E.; Blasco, P.; Li, Y.; Jiang, T.*; Li, X.*
Triazin-pyridine chemistry for selective tyrosine labelling of proteins.
Chem. Commun. 2022. 58, 7066-7069.

123.  Liu, J.; Wei, T.; Tan, Y.; Li, X.*
Enabling chemical protein (semi)synthesis via Reducible solubilizing tags (RST).
Chem. Sci. 2022. 13, 1367.

122.  Cheung, C. H. P.; Chow, H. Y.; Li, C.; Chen, K.; Chen, S.; Li X.*
Synthesis of daptomycin thiolactone analogue via the MeDbz-linker based cyclative-cleavage approach.
Pep. Sci. 2022. 114, e24255 (Awarded Paper)

121.  Li, X.*
Long journey on daptomycin.
Synlett 2022. 33, 27-33 (Invited Personal Account)


120.  Wang, J.; Li, X.*
Complex natural product synthesis via Serine/Threonine ligation.
Bioorg. Med. Chem. Lett. 2021. 43, 128430 (Invited Digest)

119.  Wei, R.; Yang, X.; Liu, H.; Wei, T.; Chen, S.*; Li, X.*
Synthetic pseudaminic-acid-based antibacterial vaccines confers effective protection against Acinetobacter baumannii infection.
ACS Cent. Sci. 2021. 7, 1535-1542

118.  Wang, J.; Lin, D.; Liu, M.; Blasco, P.; Sun, Z.; Cheung, Y.C.; Chen, S.; Liu, H.; Li, X.*
Total synthesis of mannopeptimycin β via β-Hydroxyenduracididine Ligation.
J. Am. Chem. Soc. 2021. 143, 12784-12790

117.  Sun, Z.; Li, X.*
Studies on 2-formylphenylboronic acid-based Ser/Thr ligation and Cys/Pen ligation.
Chin. J. Chem. 2021. 39, 2795-2800

116.  Wei, T.; Liu, H.; Wu, H.; Fan, P.; Li, X.*
Chemical synthesis of HMGA1a with site-specific PTMs for biochemistry study.
STAR Protocols 2021. 2, 100777

115.  Po, K. H. L.; Chow, H. Y.; Cheng, Q.; Deng, X.; Wang, S.; Chan, E. W. C.; Chan, K. F.; Li, X.*; Chen, S.*
Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2.
Natural Science 2021. 1:e10023

114.  Unarta, I. C.; Xu, J.; Shang, Y.; Cheung, C. H. P.; Zhu, R.; Chen, X.; Cao, S.; Bierer, D.; Zhang, M.; Huang, X*; Li, X.*
Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
RSC Chem. Biol. 2021. 2, 1274-1284

113.  Wu, H.; Zhang, Y.; Li, Y.; Xu, J.; Wang, Y.*; Li, X.*
Chemical Synthesis and Biological Evaluation of Adiponectin Collagenous Domain Glycoforms.
J. Am. Chem. Soc. 2021, 143, 7808-7818.

112.  Blasco, P.; Zhang, C.; Chow, H. Y.; Chen, G.; Wu, Y.; Li, X.*
An atomic perspective on improving daptomycin’s activity.
Biochim Biophys Acta Gen Subj. 2021, 1865, 129918.

111.  Zhang, B.Z., Wang, X., Yuan, S., Li, W., Dou, Y., Poon, V.K.M., Chan, C.C.S., Cai, J.P., Chik, K.K., Tang, K., Chan, C.C.Y., Hu, Y.F., Hu,J.C., Badea, S.R., Gong, H.R., Lin, X.S., Chu, H., Li, X., To, K.K., Liu, L., Chen, Z.W., Hung, I.F.N., Yuen, K.Y.
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters.
Emerging Microbes & Infection 2021, 10, 874-884.

110.  Cheung, C.; Xu, J.; Lee, C. L.; Zhang, Y.; Wei, R.; Bierer, D.; Huang, X.; Li, X*
Construction of diverse peptide structural architectures via chemical ligation.
Chem. Sci. 2021, 12, 7091-7097. (highlight by ChemistryWorld)

109.  Guo, X., Chen, X., Cheng, Y., Chang, X., Li, X.*, Li, P.*
Organocatalytic Enantioselective [2+4]-Annulation of γ-Substituted Allenoates with N-Acyldiazenes for Synthesis of Optically Active 1,3,4-Oxadiazines.
Org. Biomol. Chem. 2021, 19, 1727-1731.

108.  Wei, T.; Liu, H.; Chu, B.; Blasco, P.; Liu, Z.; Tian, R.; Li, X. D.; Li, X.*
Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins.
Cell Chem. Biol. 2021, 28, 722-732.


107.  Tan, Y.; Wei, T.; Wu, H. Li, X.*
Chemical protein synthesis: advances, challenges and outlooks.
J. Am. Chem. Soc. 2020, 142, 20288-20298.

106. Zhang, Q.; Ren, Q.; Li, X.*
Development of DHQ-based chemical biology probe to profile cellular targets for HBV.
Bioorg. Med. Chem. Lett. 2021, 30, 127615.

105.  Sun, Z.; Shang, Z.; Forelli, N.; Po, K. H. Y.; Chen,S.; Brady, S. F.; Li X.*
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation Mediated Cyclization and Absolute Structure Establishment.
Angew. Chem. Int. Ed. 2020, 15, 19868-19872. (hot paper)

104.  Chen, D., Tian, L., Po, K. H. L., Chen, S., & Li, X.* Total synthesis and a systemic structure-activity relationship of WAP-8294A2. Bioorg. Med. Chem. 2020, 28, 115677.

103.  Xu, C.; Chen, K.; Chan, K. F.; Chan, E. W. C.; Guo, X.; Chow, H. Y.; Zhao, G.; Zeng, P.; Wang, M.; Zhu, Y.; Li, X.; Wong, K-Y.; Chen, S.* Imidazole type antifungal drugs are effective colistin adjuvants that resensitize colistin-resistant Enterobacteriaceae. Adv. Therap. 2020, 2000084.

102.  Chow, H. Y.; Po, K. H. L.; Jin, K.; Qiao, G.; Sun, Z.; Ma, W.; Ye, X.; Zhou, N.; Chen, S.; Li, X.* Establishing the structure-activity relationship of daptomycin. ACS Med. Chem. Lett. 2020, 11, 1442-1449. [Pubmed]

101.  Zhang, Q.; Zhang, Y.; Li, X.* Ortho-Phthalaldehyde (OPA)-based chemoselective peptide bioconjugation and peptide cyclization. Methods in Enzymology. 2020, 639, 237-261.

100.  Chen, D.; Blasco, P.; Po, K. H. L.; Chen, S.; Li, X.* Convergent synthesis of calcium-dependent antibiotics 3a (CDA3a) and tis analogues with improved antibacterial activity via late-stage serine ligation. Org. Lett. 2020, 22, 4749-4753. [Pubmed]

99.  Tan, Y.; Li, J.; Jin, K.; Liu, J.; Chen, Z.; Yang, J.; Li, X.* Cysteine/Penicillamine ligation independent of terminal steric demands for protein chemical synthesis. Angew. Chem. Int. Ed. 2020, 59, 12741-12745. (Selected by Faculty Opinions) [Pubmed]

98.  Chow, H. Y.; Chen, D.; Li, X.* Improved Total Synthesis of the Antibiotic A54145. Org. Biomol. Chem. 2020, 18, 4401.

97.  Chow, H. Y.; Po, K. H. L.; Gao, P.; Blasco, P.; Wang, X.; Li, C; Ye, L.; Jin, K.; Chen, K.; Chan, E. W. C.; You, X.; Kao, R. Y. T.; Chen, S.; Li, X.* Methylation of daptomycin leading to the discovery of kynomycin, a cyclic lipodepsidepeptide active against resistant pathogens. J. Med. Chem. 2020, 63, 3161. [Pubmed]

96.  Du, L.; Yan, Z.; Zhu, Z.; Cheng, S-C.; Zhang, Y.; Li, X.; Tang, W-J.; Philips, D. L. Time-resolved spectroscopic observation of diphenylnitrenium ion reactions with guanosine. J. Org. Chem. 2020, 85, 14, 8792–8797.

95.  Wang, J.; Xiong, Z.; Liu, M.; Li, X.; Zheng, J.; Zhan, X.; Ding, W.; Chen, J.; Li, X.; Li, X. D.; Feng, S.; Tang, J*. Rational design of reversible redox shuttle for highly efficient light-driven microswimmer. ACS Nano, 2020, 14, 3272.

94.  Zhang, Q.; Zhang, Y.; Liu, H.; Chow, H. Y.; Tian, R.; Li, X.* OPA-based bifunctional linker for protein labeling and profiling. Biochemistry. 2020, 59, 175-178 [Pubmed]


93.  Zhang, Y.; Zhang, Q.; Wong, C.; Li, X.* Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides. J. Am. Chem. Soc. 2019, 141, 12274-12279.[Pubmed]

92.   Chow, H. Y.; Li, X.* Ligation Technologies for the synthesis of cyclic peptides. Chem. Rev. 2019, 119, 9971-10001.[Pubmed]

91.  Matheson, E.; Jin, X.; Li, X.* Establishing the structure-activity relationship of teixobactin. Chin. Chem. Lett. 2019, 30, 1468-1480

90.   Chen, D.; Chow, H. Y.; Po, K.; Ma, W.; Leung, E.; Sun, Z.; Liu, M.; Chen, S.; Li, X.* Total synthesis and structural establishment/revision of the antibiotic A54145. Org. Lett. 2019, 21, 5639-5644.

89.   Wei, R.; Liu, H.; Tang, A.; Payne R.; Li, X.* A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation. Org. Lett. 2019, 21, 3584-3588

88.  Wang, C.; Yu, Y.; Su, Z.; Li, X*.; Cao, H.* Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes. Org. Lett. 2019, 21, 442.

87.  Liu, H.; Liu, H.; Li, X.* Use of Ser/Thr ligation for the total chemical synthesis of HMGA1a protein with site-specific lysine acetylations. ChemPlusChem. 2019, 84.7: 779-785.

86.   Wei, R.; Liu, H.; Li, X.* De novo synthesis of novel bacterial monosaccharide fusaminic acid. J. Antibio. 2019, 72, 420-431

85.   Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J. Site-selective lysine reactions guided by protein-protein interaction. Biochemistry. 2019, 58, 1010.

84.  Tse, C. K.; Xu, J.; Xu, L.; Sheong, F. K.; Wang, S.; Chow, H. Y.; Gao, X.; Li, X.; Cheng, P. P. H.; Wang, D.; Zhang, Y.; Huang, X. Intrinsic cleavage of RNA polymerase II adopts a nucleobase-independent mechanism assisted by transcript phosphate. Nature Catalysis, 2019, 2, 228-235. DOI: 10.1038/s41929-019-0227-5.


83.   Andolina, G.; Wei, R.; Liu, H.; Zhang, Q.; Yang, X.; Cao, H.; Chen. S.; Yan, A.; Li, X. D.; Li, X.* Metabolic Labeling of Pseudaminic Acid-Containing Glycans on Bacterial Surfaces. ACS Chem. Biol. 2018, 13, 3030.

82.   Liu, H.; Li, X.* Serine/Threonine Ligation: Origin, Mechanistic Aspects and Applications. Acc. Chem. Res. 2018, DOI: 10.1021/acs.accounts.8b00151

81.   Jin, K.; Li, X.* Advances in NCL-Desulfurization: A powerful strategy for peptide and protein synthesis. Chem. Eur. J. 2018, DOI: 10.1002/chem.201802067

80.  Cui, Z.; Zhu, B.; Li, X.*; Cao, H.* Access to Sulfonylated Furans or Imidazo[1,2-]pyridines via a Metal-free Three-component, Domino Reaction. Front. Org. Chem. 2018, 5, 2219.

79.  Yang, D.; Yu, Y.; Wu, Y.; Feng, H.; Li, X.*; Cao, H.* One-Pot Regiospecific Synthesis of Indolizines: A Solvent-free, Metal-free, Three-Component Reaction of 2-(Pyridin-2-yl)acetates, Ynals and Alcohols or Thiols. Org. Lett. 2018, 20, 2477.

78.  Xu, C.; Xu, J.; Li, X.* Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation. Chin. Chem. Lett. 2018, 29, 1119.

77.  Cheng, Y.; Li, X.; Tse, H. F.; Rong, J. Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress. Oxid. Med. Cell. Longev. 2018, 1081287

76.  Jin, K.; Po, K. H. L.; Kong, W. Y.; Lo, C. H.; Lo, C. W.; Lam, H. Y.; Sirinimal, A.; Reuven, J. A.; Chen, S.; Li, X.* Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine. Bioorg. Med. Chem. 2018, 26, 1062. (Kong, W. Y., Lo, C. H.; Lo, C. W.; Lam, H. Y.; Sirinimal, A., Reuven, J. A. are undergraduates).


75.   Wang, C.; Lai, J.; Chen, C.; Li, X.*; Cao, H.* J.(2017). Ag-Catalyzed Tandem Three-Component Reaction toward the Synthesis of Multisubstituted Imidazoles.

74.   Jin, K., Li, T., Chow, H. Y., Liu, H &Li, X.* (2017). P‐B desulfurization: an enabling method for protein chemical synthesis and site‐specific deuteration. Angewandte Chemie International Edition. [Pubmed]

73.  Liu, H., Zhang, Y., Wei, R., Andolina, G., & Li, X.* (2017). Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de novo Synthesis of Pseudaminic Acid. Journal of the American Chemical Society. [Pubmed]

72.  Jin, K.; Po, K. H. L.; Wang, S.; Reuven, J. A.; Wai, C. N.; Lau, H. T.; Chan, T. H. Chen, S.*; Li, X.*Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation. Bioorg. Med. Chem. 2017, 17, 30587. (Wang, S., Reuven, J. A., Wai, C. N., Lau, H. T., and Chan, T. H are undergraduates)

71.  Lin, D.; Lam, H. Y.; Han, W.; Cotroneo, N.; Pandya, B. A.*; Li, X.* Structure-activity relationship of daptomycin analogues with substitution at (2S, 3R) 3-methyl glutamic acid position. Bioorg. Med. Chem. Lett. 2017, 3, 456. ( Han, W. is an undergraduate student)

70.  Cheng Y, Feng Y, Xia Z, Li X, Rong J. Biochim Biophys Acta. 2017, 1862(12):1595-1605

69.  Cheng, Y. Y.; Luo, D.; Xia, Z.; Tse, H. F.; Li, X.; Rong, J.* Arch. Immunol. Ther. Exp. (Warsz). 2017, 65, 145.


68.   Li, T., Liu, H., & Li, X.* (2016). Chemical Synthesis of HMGA1a Proteins with Post-translational Modifications via Ser/Thr Ligation. Organic letters, 18(22), 5944-5947.

67.   Lee, C. L., Liu, H., Wong, C. T., Chow, H. Y., & Li, X.* (2016). Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches. Journal of the American Chemical Society, 138(33), 10477-10484. [Pubmed]

66.   Jin, K., Sam, I. H., Po, K. H. L., Zadeh, E. H. G., Chen, S., Yuan, Y., & Li, X.* (2016). Total synthesis of teixobactin. Nature communications, 7. 12394 [Pubmed]

65.   Tung, C. L., Wong, C. T., Fung, E. Y. M., & Li, X.* (2016). Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification. Organic letters, 18(11), 2600-2603.

64.   Lee, C. L.; Li, X.* Science China Chem. (invited perspective). 2016

63.   Cheng, Y.; Luo, D.; Xia, Z.; Tse, H. F.; Li, X.; Rong, J. Arch. Immunol. Ther. Exp. 2016

62.   Cheng, Y.; Tse, H. F.; Li, X.; Han, Y.; Rong, J. Mol. Immunol. 2016, 74, 39.

61.   Liu, M.; Li, M. D.; Huang, J.; Li, T.; Liu, H.; Li, X.; Philips, D. L.* Sci. Rep. 2016, 6, 21606


60.   Jin, K., Li, S., Li, X., Zhang, J., Xu, W., & Li, X. (2015). Design, synthesis and preliminary biological evaluation of indoline-2, 3-dione derivatives as novel HDAC inhibitors. Bioorganic & medicinal chemistry, 23(15), 4728-4736.

59.   Du, L.; Li, M-D.; Zhang, Y.; Xue, J.; Zhang, X.; Zhu, R.; Cheng, S.; Li, X.; Phillips, D. L.* J. Org. Chem. 2015, 15, 7340.

58.   TLingáTung, C., Clarence, T. T. & Li, X. (2015). Peptide 2-formylthiophenol esters do not proceed through a Ser/Thr ligation pathway, but participate in a peptide aminolysis to enable peptide condensation and cyclization. Organic & biomolecular chemistry, 13(25), 6922-6926.

57.   Lee, C. L.; Lam. Y. H.; Li, X.* Serine/threonine ligation for natural cyclic peptide syntheses. Nat. Prod. Rep. (invited) 2015, 32, 1274.

56.   Development of Thiol-independent Peptide Ligations for Protein Chemical Synthesis. Chow, H. Y.; Li, X.* Tetrahedron Lett. (invited Digest), 2015, 55, 5525.

55.   Development of stapled helical peptides to perturb the Cdt1-Mcm6 interaction Lee. P.; Liu, C.; Li, T.; Zhu, G.; Li, X.* J. Pept. Sci. (invited) 2015, 7, 593. (Lee, P. is an undergraduate student)

54.   Wang, S.; Liu, K.; Seneviratne, C. J.; Li, X.; Cheung, G. S.; Jin, L.; Chu, C. H.; Zhang C. Biomed. Rep. 2015, 5, 697.


53.   A facile synthesis of sialylated oligolactosamine glycans from lactose via the Lafont intermediate Peng, P.; Liu, H.; Gong, J.; Nicholls, J. M.; Li, X.* Chem. Sci. 2014, 5, 3634.

52.   A stereoselective ring-closing glycosylation via nonglycosylating pathway. Liu, H.; Li, X.* J. Org. Chem. 2014, 79, 5834.

51.   Synthesis of cyclogentiotriose by macrocyclization via a ring-closing glycosylation. Liu, H.; Li, X.* Tetrahedron Lett. 2014, 55, 5525.

50.   A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B. Guo, J.; Xu, C.; Li, X.*; Chen, S.* PLOS One 2014, DOI: 10.1371/journal.pone.0114124

49.   Serine/Threonine ligation for the chemical synthesis of proteins. Lee, C. L.; Li, X.* Curr. Opin. Chem. Biol. (invited) 2014, 22, 108-114.

48.   A journey to the total synthesis of daptomycin. Lam, H. Y.; Li, X.* Chem. Rec. (invited) 2014, 6, 1086.

47.   Effective synthesis of cyclic peptide yunnanin C and analogues via Ser/Thr ligation (STL)-mediated peptide cyclization. Wong, C. T.; Lam, H. Y.; Li, X.* Tetrahedron (invited) 2014, 70, 7770.

46.   Adding a functional handle to nature's building blocks: the asymmetric synthesis of beta-hydroxyl-alpha-amino acids. Zhang, Y.; Farrants, H.; Li, X.* Chem. Asian J. (invited) 2014, 9, 1752.

45.   Realizing serine/threonine ligation: scope and limitations and mechanistic implication thereof.Wong, C. T.; Li, T.; Lam, H. Y., Zhang, Y.; Li, X.* Front. Chem. Biol. 2014, doi: 10.3389/fchem.2014.00028

44.   Development and application of serine/threonine ligation for synthetic protein chemistry. Liu, H.; Li, X.* Org. Biomol. Chem. (invited perspective) 2014, 12, 3768

43.   Tung, Serine/Threonine ligation in cyclizing peptides. Lam, H. Y.; Li, X.* Synlett 2014, 25, 1339. (invited Synpacts Article)

42.   A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation. Tung, C. L.; Lam, H. Y.; Xu, J.; Li. X.* Chem. Commun. 2014, 50, 5298. (the Emerging Investigators 2014 issue)

41.   Yang, C.; Li, X.; Rong, J. Chin. Med. 2014. doi: 10.1186/1749-8546-9-23.

40.   Yang, C.; Zhao, J.; Cheng, Y.; Li, X.; Rong, J. Biomed. Res. Int. 2014, doi: 10.1155/2014/306857

39.   Glycopeptide/glycoprotein synthesis. Xu, C.; Li, X.* book chapter, Glycoscience: Biology and Medicine, 2014


38.   Synthesis of Constrained Head-to-Tail Cyclic Tetrapeptides by an Imine-induced Ring Closing-Contraction Strategy. Wong, C. T. T.; Lam, H. Y.; Song, T.; Chen, G.*; Li, X.* Angew. Chem. Int. Ed. 2013, 52, 10212.
Highlighted by Society of Chemical Industry-Biomedical highlights;
Selected for Synlett. (Synpacts). 2014, 25, 1339

37.   Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation. Lam, H. Y.; Zhang, Y.; Liu, H.; Xu, J.; Wong, C. T.; Li, X.* J. Am. Chem. Soc. 2013, 135, 6272.
Selected by the Chemical Record 2014, 6, 1086

36.   Protein chemical synthesis by serine and threonine ligation. Zhang, Y.; Xu, C.; Lam, H. Y.; Lee, C. L; Li, X.* Proc. Natl. Acad. Sci. USA, 2013, 110, 6657.
Selected by Faculty1000 prime

35.   Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B. Wong, C. T. T. ; Lam, H. Y.; Li, X.* Org. Biomol. Chem. 2013, 11, 7616.

34.   Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL) Zhang, Y.; Li, T.; Li, X.* Org. Biomol. Chem. 2013, 11, 5584.

33.   Convergent synthesis of MUC1 glycopeptides via serine ligation Xu, C.; Lam, H. Y.; Zhang, Y.; Li, X.* Chem. Commun. 2013, 49, 6200.

32.   Synthetic cysteine surrogates used in native chemical ligation. Wong, C. T. T.; Tung, C. L.; Li, X.* Mol. Biosyst. 2013, 9, 826.

31.   Li, M.; Su, T.; Ma, J.; Liu, H.; Li, X.; Phillips, D. L.* Chem. Eur. J. 2013, 19, 11241

30.   Xu, C.; Bai, B.; Fan, P.; Cai, Y.; Huang, B.; Law, I, K,; Liu, L.; Xu, A.; Tung, C.; Li, X.; Siu, F. M.; Che, C. M.; Vanhoutte, P. M.; Wang, Y.* Am. J. Transl. Res. 2013, 5, 412.


29.   A three-component reaction toward the synthesis of 1-carboxamido-isoindoles. Zhang, Y.; Lee, C. L.; Liu, H.; Li, X.* Org. Lett. 2012, 14, 5146.

28.   Synthesis of protected sugar-amino acid hybrid molecules as platform for further derivatization. Liu, H,; Li, X.* Tetrahedron Lett. 2012, 53, 6957.

27.   Studies on the sialylation of galactoses with different C-5 modified sialyl donors. Gong, J.; Liu, H.; Nicholls, J. M.; Li, X.* Carbohydr. Res. 2012, 361, 91.


26.   Click to join peptides/proteins together. Li, X. Chem. Asian J. 2011, 6, 2606.

25.   The multidrug efflux pump MdtEF protects against nitrosative damage during the anaerobic respiration in Escherichia coli. Zhang, Y.; Xiao, M.; Horiyama, T.; Zhang, Y.; Li, X.; Nishino, K.; Yan, A. J. Bio. Chem. 2011, 286, 26576.

24.   Thioglycosylation of 1,2-cis-glycosyl acetates: a long-standing overlooked issue in preparative carbohydrate chemistry. Xu, C.; Liu, H.; Li. X.* Carbohydr. Res, 2011, 346, 1149.


23.   Salicylaldehyde ester-induced chemoselective peptide ligations: enabling generation of natural peptidic linkages at the serine/threonine sites. Li, X.*; Lam, H. Y.; Zhang, Y.; Chan, C. K. Org. Lett. 2010, 12, 1724.

Prior to HKU

23.   Wilson, R. M.; Stockdill, J. L.; Wu, X.; Li, X.; Vadola, P. A.; park, P. K.; Wang, P.; Danishefsky, S. J. Angew. Chem. Int. Ed. 2012, 51, 2834

22.   Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y. Wu, X.; Danishefsky, S. J. J. Am. Chem. Soc. 2011, 133, 1597

21.   Rao, Y.; Li, X.; Nagorny, P.; Hayashida, J. Danishefsky, S. J. Tetrahedron Lett. 2009, 50, 6684.

20.   Rao, Y.; Li, X.; Danishefsky, S. J. J. Am. Chem. Soc. 2009, 131, 12924.

19.   Nagorny, P.; Fasching, B.; Li, X.; Chen, G.; Aussedate, B.; Danishefsky, S. J. J. Am. Chem. Soc. 2009, 131, 5792.

18.   Wu, X.; Yuan, Y.; Li, X.; Danishefsky. S. J. Tetrahedron Lett. 2009, 50, 4666.

17.   Yuan, Y.; Zhu, J.; Li, X.; Wu, X.; Danishefsky, S. J. Tetrahedron Lett. 2009, 50, 2329.

16.   Wu, X.; Li, X.; Danishefsky, S. J. Tetrahedron Lett. 2009, 50, 1523.

15.   Li, X.; Yuan, Y.; Kan, C.; Danishefsky. S. J. J. Am. Chem. Soc. 2008, 130, 13225.

14.   Li, X.; Yuan, Y.; Berkowitz, W. F.; Todaro, L. J.; Danishefsky, S. J. J. Am. Chem. Soc. 2008, 130, 13222.

13.   Li, X.; Danishefsky, S. J. Nature Protocols 2008, 3, 1666.

12.   Jones, G, O.; Li, X,; Hayden, A. D.; Houk, K. N.; Danishefsky, S. J. Org. Lett. 2008, 10, 4093.

11.   New Chemistry with Old Functional Groups: On the Reaction of Isonitriles with Carboxylic Acids-A route to Various Amide Types. Li, X.; Danishefsky, S. J. J. Am. Chem. Soc. 2008, 130, 5446.

10.   Taylor, J. G.; Li, X.; Oberthur, M.; Zhu, W.; Kahne, D. J. Am. Chem. Soc. 2006, 128, 15084.

9.   Gennadios, H. A.; Whittington, D. A.; Li, X.; Fierke, C. A.; Christianson, D. A. Biochemistry 2006, 45, 7940.

8.   Li, X.; McClerren, A. L.; Raetz, C. R. H.; Hindsgaul, O. J. Carbohydr. Chem. (invited paper, special issue in memoriam Jacques van Boom) 2005, 24, 583

7.   Coggins, B. E.; McClerren, A. L.; Jiang, L.; Li, X.; Rudolph, J.; Hindsgaul, O.; Raetz, C. R. H.; Zhou, P. Biochemistry 2005, 44, 1114.

6.   Coggins, B. E.; Li, X.; Hindsgaul, O.; Raetz, C. R. H.; Zhou, P. J. Biomol. NMR 2004, 82, 201.

5.   Coggins, B. E.; Li, X.; McClerren, A, L.; Hindsgaul, O.; Raetz, C. R. H.; Zhou, P. Nature Struct. Biol. 2003, 10, 645.

4.   Li, X.; Uchiyama, T.; Raetz, C. R. H.; Hindsgaul, O. Org. Lett. 2003, 5, 539.

3.   Liu, L.; Li, C.; Li, X.; Yuan, Z.; An, Y.; He, B. J. Appl. Polym. Sci. 2001, 80, 1976.

2.   Wu, Q.; Li, C.; Li, X.; Li, Y. Spectrosc. Spect. Anal. 2001, 21, 778.

1.   Wu, Q.; Li, C.; Li, X. Chem. R. Chinese U. 2001, 22, 2123.